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What can 6,000 brain scans tell us about Alzheimer's? (opens in a new tab)

news-medical.net · 2026-10-23

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What can 6,000 brain scans tell us about Alzheimer's?

news-medical.net · 2026-10-23

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Exploring healthy aging through preclinical Alzheimer disease in the Knight Alzheimer Research Imaging dataset

Nature Communications · 2026

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Claim 1 of 5Not checkedA new paper in Nature Communications describes the Knight Alzheimer Research Imaging (KARI) dataset, a large longitudinal multimodal resource spanning healthy aging, preclinical Alzheimer's disease, and symptomatic disease.View evidenceHide evidence

As statedmore than 6,200 brain scans; 1,645 participants

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Claim 2 of 5Not checkedThe dataset included 6,217 neuroimaging acquisitions from 1,645 participants aged 42–97 years, with MRI, amyloid PET, tau PET, clinical, cognitive, genetic, and fluid biomarker data.View evidenceHide evidence

As stated6,217 neuroimaging acquisitions; 1,645 participants; 42–97 years

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Claim 3 of 5Not checkedGreater cortical thickness was associated with better cognitive performance, while higher amyloid and tau burden were associated with poorer performance on the Knight PACC.View evidenceHide evidence

As statedpartial correlations of 0.36, -0.33, and -0.40

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Claim 4 of 5Not checkedBrain imaging markers such as cortical signature, amyloid burden, tau index, tau spatial spread, white matter hyperintensity volume, and microbleeds varied with age and clinical impairment.View evidenceHide evidence

As statedCDR 0 to CDR 2; mean tau spatial spread approximately 0.052 to 0.682

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Claim 5 of 5Not checkedThe authors present KARI as a resource that could support hypothesis generation, biomarker validation, and future studies of disease mechanisms, earlier detection, and refinement of disease models.View evidenceHide evidence

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Exploring healthy aging through preclinical Alzheimer disease in the Knight Alzheimer Research Imaging dataset

Nature Communications · 2026

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