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Vanderbilt researchers create massive transcriptomic atlas of breast cancer (opens in a new tab)
news-medical.net · 2026-11-03
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Vanderbilt researchers create massive transcriptomic atlas of breast cancer
news-medical.net · 2026-11-03
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An integrated breast cancer transcriptomic atlas defines clinical subtypes and informs cellular origin
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Claim 1 of 4Not checkedResearchers at Vanderbilt-Ingram Cancer Center published a study in Cell Reports Medicine on Nov. 3 that generated one of the largest transcriptomic maps of breast cancer ever assembled, integrating data from more than 7,600 tumors across 22 independent studies.View evidenceHide evidence
As statedmore than 7,600 tumors across 22 independent studies
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Claim 2 of 4Not checkedThe atlas provides an unprecedented view of breast cancer’s molecular diversity and reveals distinct tumor populations associated with different clinical outcomes, biological characteristics, and therapeutic vulnerabilities.View evidenceHide evidence
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Claim 3 of 4Not checkedThe study says estrogen receptor-low breast cancers behave more like ER-negative disease, identifies subsets of HER2-positive tumors that may benefit from HER2 kinase inhibitors, uncovers a hidden neuroendocrine form associated with worse outcomes after standard chemo-endocrine therapy and possible FGFR1 targeting, and defines a biologically distinct aggressive basal-luminal progenitor triple-negative subtype with potential vulnerabilities to RTK/MAPK-targeted and anti-angiogenic therapies.View evidenceHide evidence
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Claim 4 of 4Not checkedResearchers also created a tool that can assign tumors to subtypes using standard bulk RNA sequencing data, with the goal of guiding future research studies and clinical trials; they say prospective testing is needed to determine whether subtype-guided treatment improves outcomes.View evidenceHide evidence
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An integrated breast cancer transcriptomic atlas defines clinical subtypes and informs cellular origin
Cell Reports Medicine · 2026
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Papers considered
The selected paper, plus nearby candidates.
Crossref, PubMed, Europe PMC · 16 candidate papers
An integrated breast cancer transcriptomic atlas defines clinical subtypes and informs cellular origin
Cell Reports Medicine · 2026 · Crossref
Immune-evasion-associated prognostic gene expression score stratifies survival and immune microenvironment features in breast cancer.
Biomolecules & Biomedicine · 2026 · PubMed
SECTION II: MOLECULAR AND CELLULAR MARKERS OF PROGNOSIS
Breast Cancer · 2007 · Crossref
Spatial Transcriptomics in Breast Cancer: Advances and Applications.
2026 · Europe PMC
Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq.
Nature Biotechnology · 2026 · PubMed
The therapeutic response of ER+/HER2− breast cancers differs according to the molecular Basal or Luminal subtype
Npj Breast Cancer · 2020 · Crossref
And 10 more candidates considered.