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Unstable immune cells linked to severe cancer immunotherapy side effects (opens in a new tab)
news-medical.net · 2026-10-22
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Unstable immune cells linked to severe cancer immunotherapy side effects
news-medical.net · 2026-10-22
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Source study identified.
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Lifestyle-induced regulatory T cell fragility primes adverse events after immune checkpoint blockade
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Claim 1 of 8Not checkedScientists at the University of Pittsburgh uncovered unstable immune cells that can cause up to 40% of immunotherapy patients to experience serious side effects.View evidenceHide evidence
As statedup to 40%
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Claim 2 of 8Not checkedThe study, published today in Cell, found that the inflammation can be reversed in mice by shutting off a protein in 'fragile' immune cells.View evidenceHide evidence
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Claim 3 of 8Not checkedThe researchers say there are no FDA-approved treatments for immune-related adverse events, a serious side effect of immune checkpoint inhibitors, and that up to 25% of patients receiving immune checkpoint inhibitors experience severe adverse events.View evidenceHide evidence
As statedup to 25%
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Claim 4 of 8Not checkedThe team created a mouse model of immune-related adverse events by feeding mice a Western-style diet before and during immune checkpoint inhibitor treatment.View evidenceHide evidence
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Claim 5 of 8Not checkedMice on the Western-style diet showed regulatory T cell fragility, and researchers observed the same fragility in regulatory T cells from immunotherapy patients with severe immune-related adverse events but not in patients without the side effect.View evidenceHide evidence
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Claim 6 of 8Not checkedRestoring the cells' stability significantly reduced the severity of immune-related adverse events, and the researchers say this suggests regulatory T cell fragility is a major underlying cause of the side effect.View evidenceHide evidence
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Claim 7 of 8Not checkedThe team says stability could be restored by blocking an immune signaling protein on regulatory T cells, switching the mice to a high-fiber diet, or giving metabolite supplementation.View evidenceHide evidence
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Claim 8 of 8Not checkedFecal microbiome transfers and patient microbiome transfers suggested the microbiome influences the severity of immune-related adverse events, and the authors say diet and the gut microbiome are responsible for these toxic side effects.View evidenceHide evidence
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Lifestyle-induced regulatory T cell fragility primes adverse events after immune checkpoint blockade
Cell · 2026
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Papers considered
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Lifestyle-induced regulatory T cell fragility primes adverse events after immune checkpoint blockade
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