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Testosterone therapy may increase risk of cardiovascular disease in postmenopausal women (opens in a new tab)
medicalxpress.com · 2026-10-20
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Testosterone therapy may increase risk of cardiovascular disease in postmenopausal women
medicalxpress.com · 2026-10-20
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Source study unconfirmed.
We could not identify a single source study for this article. It may discuss broader research or report findings from a source other than a research paper.
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Testosterone therapy and cardiovascular risk in postmenopausal women: a retrospective propensity-matched cohort study
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Claim 1 of 7Not checkedA new study links testosterone therapy in postmenopausal women with a higher risk of incident cardiovascular disease.View evidenceHide evidence
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NewsLink could not identify one source study, so this claim was not compared against a paper.
Claim 2 of 7Not checkedTestosterone therapy is not routinely recommended for postmenopausal women, in part because long-term safety data remain limited, though it is sometimes prescribed off label for low libido.View evidenceHide evidence
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NewsLink could not identify one source study, so this claim was not compared against a paper.
Claim 3 of 7Not checkedThe study used data from the TriNetX US Collaborative Network and included more than 6,300 propensity-matched menopausal women.View evidenceHide evidence
As statedmore than 6,300 propensity-matched menopausal women
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NewsLink could not identify one source study, so this claim was not compared against a paper.
Claim 4 of 7Not checkedPostmenopausal women 45 and older who initiated testosterone therapy were compared with women without testosterone exposure, after a 12-month washout and exclusion of women with prior cardiovascular disease.View evidenceHide evidence
As stated12-month washout; mean follow-up nearly three years
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NewsLink could not identify one source study, so this claim was not compared against a paper.
Claim 5 of 7Not checkedResearchers concluded that testosterone therapy was associated with a significantly increased hazard of incident composite cardiovascular disease compared with no testosterone exposure (3.8% vs. 0.5%; hazard ratio, 8.08; 95% confidence interval, 4.72–13.82).View evidenceHide evidence
As stated3.8% vs. 0.5%; hazard ratio 8.08
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NewsLink could not identify one source study, so this claim was not compared against a paper.
Claim 6 of 7Not checkedThe findings were consistent in sensitivity analyses comparing women receiving testosterone plus hormone therapy with women receiving hormone therapy alone, and absolute event rates were low.View evidenceHide evidence
As statedabsolute event rates were low
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NewsLink could not identify one source study, so this claim was not compared against a paper.
Claim 7 of 7Not checkedThe composite cardiovascular outcome included coronary artery disease, cerebrovascular disease, or heart failure occurring 30 days to five years after the index date.View evidenceHide evidence
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NewsLink could not identify one source study, so this claim was not compared against a paper.
Method layer
No single source study was found.
The search results are available for you to inspect. Without a confirmed source study, they cannot establish whether the story’s claims are supported or contradicted.
Search results
Candidate papers, not confirmed sources.
PubMed, Europe PMC, Crossref · 15 candidate papers
Effects of testosterone on exercise capacity in postmenopausal women with stage B heart failure.
Climacteric : the Journal of the International Menopause Society · 2026 · PubMed, Europe PMC
Estradiol/Testosterone Ratio as a Predictor of Coronary Artery Disease in Postmenopausal Women: A Useful Tool!
Indian Journal of Cardiovascular Disease in Women · 2021 · Crossref
Testosterone therapy for female sexual dysfunction: a systematic review of the literature demonstrating outcomes in premenopausal and postmenopausal women.
2026 · Europe PMC
Silent Ovary with a Loud Hormonal Signal: A Case Report and Literature Review of an Androgen-Secreting Stromal Luteoma.
Journal of Clinical Medicine · 2026 · PubMed
Alterations of oestradiol, testosterone, gonadotrophins and SHBG by type 2 diabetes in postmenopausal women
Practical Diabetes International · 2007 · Crossref