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Study identifies potential new treatment targets for the most common type of bowel cancer (opens in a new tab)
medicalxpress.com · 2026-10-23
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Study identifies potential new treatment targets for the most common type of bowel cancer
medicalxpress.com · 2026-10-23
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Multiomic characterization of microsatellite-stable colorectal cancer reveals distinct biology and targetable vulnerabilities
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Claim 1 of 8Not checkedResearch published today identifies potential new ways to treat the most common type of colorectal cancer in Ireland.View evidenceHide evidence
As statedmost common type of colorectal cancer in Ireland
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Claim 2 of 8Not checkedThe study, led by RCSI University of Medicine and Health Sciences and The Institute of Cancer Research, London, provides a roadmap for repurposing existing drugs and developing new ones for more effective, personalized treatments.View evidenceHide evidence
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Claim 3 of 8Not checkedMicrosatellite-stable (MSS) colorectal cancer accounts for 80%–85% of the 2,500 new colorectal cancer cases diagnosed annually in Ireland and remains challenging to treat, with limited response to many newer therapies.View evidenceHide evidence
As stated80%–85% of the 2,500 new colorectal cancer cases diagnosed annually in Ireland
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Claim 4 of 8Not checkedUsing 2,000 patient tumor samples, the researchers analyzed genetic, metabolic, protein and clinical data with AI tools and found previously unrecognized ways the cancer cells divide, grow, adapt and interact with their environment.View evidenceHide evidence
As stated2,000 patient tumor samples
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Claim 5 of 8Not checkedThe team developed an AI approach called iPhenMap that can create a biological map of the tumor and reveal connections between tumor features that had been missed in previous studies.View evidenceHide evidence
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Claim 6 of 8Not checkedThe researchers tested the identified vulnerabilities in laboratory models and showed that certain drug combinations could work well to target them and treat the cancer.View evidenceHide evidence
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Claim 7 of 8Not checkedThe targeted drug trametinib was shown to significantly reduce tumor growth and extend survival in laboratory models when combined with other drugs.View evidenceHide evidence
As statedsignificantly reduce tumor growth and extend survival
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Claim 8 of 8Not checkedThe authors say the findings remain preclinical and could help guide further development and eventual clinical testing of treatment strategies for colorectal cancer.View evidenceHide evidence
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Multiomic characterization of microsatellite-stable colorectal cancer reveals distinct biology and targetable vulnerabilities
Cancer Cell · 2026
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Papers considered
The selected paper, plus nearby candidates.
Crossref, Europe PMC, PubMed · 39 candidate papers
Multiomic characterization of microsatellite-stable colorectal cancer reveals distinct biology and targetable vulnerabilities
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