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Stroke may change brain cells in ways that help gliomas grow (opens in a new tab)

medicalxpress.com · 2026-09-25

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Claim 1 of 5Not checkedResearchers at Texas Children's Duncan Neurological Research Institute, Baylor College of Medicine and collaborators report in Nature Cancer that stroke promotes glioma growth and links brain injury to malignant brain tumors.View evidenceHide evidence

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Claim 2 of 5Not checkedThe study says stroke promoted tumor infiltration into injured brain regions in human and mouse glioma models and reduced overall survival.View evidenceHide evidence

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Claim 3 of 5Not checkedThe researchers identified tumor-associated astrocytes with reduced calcium activity, along with remodeled tumor-associated microglia and macrophages, as key mediators of the stroke response.View evidenceHide evidence

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Claim 4 of 5Not checkedRestoring tumor-associated astrocyte calcium signaling or removing tumor-associated macrophages suppressed stroke-induced glioma progression.View evidenceHide evidence

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Claim 5 of 5Not checkedThe article says the findings suggest injury-induced, tumor-promoting pathways may be therapeutic targets and support further research on reducing glioma growth risk in patients with prior brain injury.View evidenceHide evidence

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Stroke drives glioma progression through the emergence of tumor-associated astrocytes with reduced Ca2+ activity

Nature Cancer · 2026

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Papers considered

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Crossref, PubMed, Europe PMC · 16 candidate papers

Selected

Stroke drives glioma progression through the emergence of tumor-associated astrocytes with reduced Ca2+ activity

Nature Cancer · 2026 · Crossref

Source (opens in a new tab)
Candidate

CNSC-19. ISCHEMIC STROKE DRIVES GLIOMA PROGRESSION BY REMODELING TUMOR-ASSOCIATED ASTROCYTES

Neuro-Oncology · 2024 · Crossref

Source (opens in a new tab)

And 10 more candidates considered.