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Sensory neurons remember past allergens to trigger future allergic reactions (opens in a new tab)

news-medical.net · 2026-09-22

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Claim 1 of 6Not checkedMass General Brigham researchers found that sensory neurons retain a 'memory' of allergens that may help explain why allergies develop over time.View evidenceHide evidence

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Claim 2 of 6Not checkedThe article says a new preclinical study led by investigators from Mass General Brigham may explain why allergies often emerge only after repeated exposure and why people with one allergy frequently develop others.View evidenceHide evidence

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Claim 3 of 6Not checkedThe new study is described as showing that sensory neurons can retain a metabolically encoded record of previous allergen exposures and respond more strongly to later exposures, even after the original allergen is gone.View evidenceHide evidence

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Claim 4 of 6Not checkedIn mice, the researchers modeled recurrent allergen exposure and found that an initial exposure activates a specific signaling pathway in neurons that primes them to respond later to the same allergen and to other allergens with the same enzymatic activity but different molecular structures.View evidenceHide evidence

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Claim 5 of 6Not checkedThe story says this cross-allergen response may help explain why developing sensitivity to one allergen can increase susceptibility to others.View evidenceHide evidence

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Claim 6 of 6Not checkedSenior author Caroline L. Sokol said the team is investigating whether allergic memory in neurons can be deliberately reset to reduce the risk of developing allergies.View evidenceHide evidence

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Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity

Immunity · 2026

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Papers considered

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Crossref, Europe PMC, PubMed · 40 candidate papers

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Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity

Immunity · 2026 · Crossref

Source (opens in a new tab)
Candidate

Author response for "Viral immunity in immunoglobulin products: global immunity debt and autoimmunity in the post pandemic era"

2026 · Crossref

Source (opens in a new tab)

And 34 more candidates considered.