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Scientists discover immune pathway behind radiation-induced lung damage (opens in a new tab)
news-medical.net · 2026-10-20
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Scientists discover immune pathway behind radiation-induced lung damage
news-medical.net · 2026-10-20
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Type I IFN promotes ILC2-to-ILC1 plasticity in pre-clinical radiation-induced lung injury
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Claim 1 of 6Not checkedCity of Hope researchers uncovered an immune pathway that may contribute to radiation-related lung damage and identified a potential strategy to block it.View evidenceHide evidence
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Claim 2 of 6Not checkedPublished in Nature Communications, the preclinical study could lead to new treatments that prevent radiation from harming healthy lung tissue and improve patients' quality of life.View evidenceHide evidence
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Claim 3 of 6Not checkedThe researchers said radiation reprograms innate lymphoid cells, shifting protective ILC2s into inflammatory ILC1s that damage healthy lung tissue.View evidenceHide evidence
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Claim 4 of 6Not checkedThe team said radiation increased interferon-beta, which acted as the switch driving the ILC2-to-ILC1 transformation; human ILC tests showed similar changes.View evidenceHide evidence
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Claim 5 of 6Not checkedIn mice, blocking IFN-beta signaling during radiation reduced inflammation, limited lung injury, and decreased fibrosis.View evidenceHide evidence
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Claim 6 of 6Not checkedIf the approach works in people, it could protect patients from long-term lung damage and expand radiation options for people with chronic lung disease such as COPD.View evidenceHide evidence
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Type I IFN promotes ILC2-to-ILC1 plasticity in pre-clinical radiation-induced lung injury
Nature Communications · 2026
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Papers considered
The selected paper, plus nearby candidates.
Crossref, PubMed, Europe PMC · 15 candidate papers
Type I IFN promotes ILC2-to-ILC1 plasticity in pre-clinical radiation-induced lung injury
Nature Communications · 2026 · Crossref
Epithelial-derived cytokines in the pathogenesis of severe asthma.
Frontiers in Allergy · 2025 · PubMed
Innate Immune Cells in Non-Small Cell Lung Cancer: Roles in Tumor Progression and Therapeutic Responses.
2026 · Europe PMC
Innate lymphoid cells are activated in HFRS, and their function can be modulated by hantavirus-induced type I interferons.
PLoS Pathogens · 2024 · PubMed
Cyclic-di-GMP Induces STING-Dependent ILC2 to ILC1 Shift During Innate Type 2 Lung Inflammation
Frontiers in Immunology · 2021 · PubMed, Crossref
Unveiling the sensing potential of innate lymphoid cells.
2026 · Europe PMC
And 9 more candidates considered.