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Researchers discover why 'zombie cells' accumulate with age (opens in a new tab)

medicalxpress.com · 2026-10-05

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Claim 1 of 6Not checkedA new study led by Albert Einstein College of Medicine researchers and published in Nature Aging helps explain why senescent ('zombie') cells become increasingly difficult to eliminate as organisms age.View evidenceHide evidence

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Claim 2 of 6Not checkedIn mice, declining activity in chaperone-mediated autophagy (CMA) impairs both senescent cells and the immune cells responsible for removing them, and restoring CMA reduced senescent-cell buildup and lessened lung fibrosis.View evidenceHide evidence

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Claim 3 of 6Not checkedIn mice whose macrophages lacked CMA, wound sites accumulated more zombie cells and wounds healed more slowly, suggesting CMA in macrophages is important for clearing senescent cells during tissue repair.View evidenceHide evidence

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Claim 4 of 6Not checkedWhen fibroblasts from young and old mice were induced to become senescent, younger cells increased CMA activity but older cells did not, and the older cells released toxic substances that made nearby healthy cells more likely to become senescent and hindered macrophage recognition and removal.View evidenceHide evidence

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Claim 5 of 6Not checkedFive months of daily oral CA77.1 treatment in aged mice reduced senescent-cell buildup in several organs and reduced signs of inflammation and fibrosis, and CA77.1 also restored engulfment ability in macrophages isolated from aged mice.View evidenceHide evidence

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Claim 6 of 6Not checkedLung samples from patients with idiopathic pulmonary fibrosis showed markedly reduced CMA activity, and CA77.1 reduced lung fibrosis severity as well as signs of senescence and inflammation in a mouse model of the disease.View evidenceHide evidence

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Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells

Nature Aging · 2026

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Crossref, Europe PMC, PubMed · 39 candidate papers

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Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells

Nature Aging · 2026 · Crossref

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