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Psilocybin may help the brain recover from concussion, new study finds (opens in a new tab)
medicalxpress.com · 2026-09-23
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Psilocybin may help the brain recover from concussion, new study finds
medicalxpress.com · 2026-09-23
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Open claim evidenceThe source study
Psilocybin as a treatment for repetitive mild head injury: evidence from neuroradiology and molecular biology
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Psilocybin as a treatment for repetitive mild head injury: evidence from neuroradiology and molecular biology
Communications Biology · 2026
- Cited as backgroundmentioned without context
Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury
Journal of Neuropathology & Experimental Neurology · 2009
- Cited as backgroundmentioned without context
Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings
JAMA Neurology · 2016
- Cited as backgroundmentioned without context
Mild TBI and risk of Parkinson disease
Neurology · 2018
- Cited as backgroundmentioned without context
What Is Psilocybin?
JAMA · 2026
- Cited as backgroundmentioned without context
Structural neural plasticity evoked by rapid-acting antidepressant interventions
Nature Reviews Neuroscience · 2025
- Cited as backgroundmentioned without context
Examining the potential of psilocybin and 5-MeO-DMT as therapeutics for traumatic brain injury
Progress in Neuro-Psychopharmacology and Biological Psychiatry · 2025
- Cited as backgroundmentioned without context
Psilocybin mitigates chronic behavioral and neurobiological alterations in a rat model of recurrent intimate partner violence-related brain injury
Molecular Psychiatry · 2026
- Cited as backgroundmentioned without context
Psilocybin restores behavior and 5-HT2A signaling while reducing microglial density after chronic traumatic brain injury in rats
Cell Reports Medicine · 2026
- Cited as backgroundmentioned without context
Neurodegenerative Disease Tauopathies
Annual Review of Pathology: Mechanisms of Disease · 2024
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Claim 1 of 7Not checkedA new study suggests psilocybin may help the brain recover from repeated mild head trauma.View evidenceHide evidence
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Claim 2 of 7Not checkedThe findings are published in Communications Biology and are based on research conducted with colleagues from the United States.View evidenceHide evidence
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Claim 3 of 7Not checkedIn middle-aged female rats that received one mild head impact per day for three consecutive days, psilocybin given shortly after each impact substantially reduced imaging evidence of vasogenic edema.View evidenceHide evidence
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Claim 4 of 7Not checkedThree weeks later, psilocybin partially normalized abnormal vascular responsiveness to carbon dioxide in several brain regions, including the prefrontal cortex.View evidenceHide evidence
As statedpartially normalized
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Claim 5 of 7Not checkedRepeated injury weakened functional connectivity between many brain regions, and psilocybin reversed this loss and produced connectivity greater than that seen in uninjured animals.View evidenceHide evidence
As statedgreater than that observed in uninjured animals
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Claim 6 of 7Not checkedPsilocybin reduced phosphorylated tau and increased BDNF and TrkB, while blood-fat changes suggested broader systemic effects.View evidenceHide evidence
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Claim 7 of 7Not checkedThe article cautions that this was an animal study in female rats, with treatment given within 30 minutes of injury, and that the drug is not ready to be considered a concussion treatment.View evidenceHide evidence
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Psilocybin as a treatment for repetitive mild head injury: evidence from neuroradiology and molecular biology
Communications Biology · 2026
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Papers considered
The selected paper, plus nearby candidates.
Crossref, PubMed, Europe PMC · 43 candidate papers
Psilocybin as a treatment for repetitive mild head injury: evidence from neuroradiology and molecular biology
Communications Biology · 2026 · Crossref
Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury
Journal of Neuropathology & Experimental Neurology · 2009 · Crossref
Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings
JAMA Neurology · 2016 · Crossref
Mild TBI and risk of Parkinson disease
Neurology · 2018 · Crossref
What Is Psilocybin?
JAMA · 2026 · Crossref
Structural neural plasticity evoked by rapid-acting antidepressant interventions
Nature Reviews Neuroscience · 2025 · Crossref
And 37 more candidates considered.