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Source study found

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Pancreatic cancer cells continuously reshape DNA to evade treatment (opens in a new tab)

news-medical.net · 2026-10-13

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Study found.

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Source paper

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The 3 papers the story cites

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The research anchor for the report.

  • The study this story reportspresented as the new finding

    Clonal heterogeneity in human pancreatic ductal adenocarcinoma and its impact on tumor progression

    Nature Genetics · 2026

    Publisher (opens in a new tab)
  • The study this story reportspresented as the new finding

    Clonal heterogeneity in human pancreatic ductal adenocarcinoma and its impact on tumor progression

    Nature Genetics · 2026

    Publisher (opens in a new tab)
  • Cited as backgroundpresented as earlier work

    https://today.ucsd.edu/story/scientists-reveal-how-pancreatic-cancer-evolves-to-evade-treatment

    Where the story links (opens in a new tab)
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Claim by claim

The source study was found, but the study's evidence could not be profiled, so these claims couldn't be checked.

Claim 1 of 5Not checkedA new analysis of nearly half a million cells from dozens of pancreatic tumors found that pancreatic cancer cells continuously reshape their genetic makeup over time, enabling them to evade treatment.View evidenceHide evidence

As stated443,451 single cells from 62 tumors in 59 people

Not checked

The source study was found, but this claim couldn't be checked against it.

Claim 2 of 5Not checkedThe study, focused on pancreatic ductal adenocarcinoma, found that within a single tumor different clones evolve in parallel, take on different identities, and interact differently with the immune and stromal landscape.View evidenceHide evidence

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The source study was found, but this claim couldn't be checked against it.

Claim 3 of 5Not checkedThe analysis suggests ongoing reshaping of cancer-cell DNA fuels both treatment resistance and metastasis, and that genetic reconfiguration enables cancer cells to transition between classical and basal subtypes.View evidenceHide evidence

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The source study was found, but this claim couldn't be checked against it.

Claim 4 of 5Not checkedThe study identified increased MYC activity in aggressive basal tumor-cell populations, and further experiments showed that blocking MYC reverted cells to the less aggressive classical form and exposed them to more immune cells.View evidenceHide evidence

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The source study was found, but this claim couldn't be checked against it.

Claim 5 of 5Not checkedThe researchers also found that TIGIT was more active in some clones while PD-1 activity was suppressed, which the article says may help explain why PD-1-targeting immunotherapies are rarely effective against PDAC.View evidenceHide evidence

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The source study was found, but this claim couldn't be checked against it.

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Open the paper in Tessa

Clonal heterogeneity in human pancreatic ductal adenocarcinoma and its impact on tumor progression

Nature Genetics · 2026

Source record (opens in a new tab)

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Papers considered

The selected paper, plus nearby candidates.

Crossref, PubMed, Europe PMC · 40 candidate papers

Selected

Clonal heterogeneity in human pancreatic ductal adenocarcinoma and its impact on tumor progression

Nature Genetics · 2026 · Crossref

Source (opens in a new tab)

And 34 more candidates considered.