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Newly discovered protein helps preserve egg chromosome integrity during aging (opens in a new tab)

news-medical.net · 2026-10-29

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We found a likely source study, but its evidence could not be prepared for claim review. The article's claims remain unverified.

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A source study was identified, but the study's evidence could not be prepared for claim assessment. The claims below have not been assessed.

Claim 1 of 7Not checkedResearchers identified a previously unknown protein, OMC1, that helps preserve chromosome cohesion in eggs from before birth to adulthood.View evidenceHide evidence

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Claim 2 of 7Not checkedThe paper, published in Nature Aging on October 29, 2026, was led by Prof. Kei-ichiro Ishiguro of Chiba University with coauthors from Chiba University and the RIKEN Center for Biosystems Dynamics Research.View evidenceHide evidence

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Claim 3 of 7Not checkedUsing single-cell RNA sequencing and delayed-meiosis mouse data, the team identified an uncharacterized gene active in oocytes before the dormant stage and named it Omc1, with the protein OMC1 localized on egg chromosomes alongside REC8 cohesin.View evidenceHide evidence

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Claim 4 of 7Not checkedIn mice lacking Omc1, REC8 cohesin disappeared from chromosomes earlier than normal, and young eggs showed weakened cohesion and chromosome-separation errors similar to those seen in aged eggs.View evidenceHide evidence

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Claim 5 of 7Not checkedRestoring OMC1 in adult oocytes partly recovered REC8 levels and reduced chromosome errors, suggesting OMC1 actively maintains REC8 on chromosomes.View evidenceHide evidence

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Claim 6 of 7Not checkedThe article says variants in the human OMC1 counterpart, CCDC201, have been associated with early menopause and loss of ovarian function, and a truncated mouse OMC1 version corresponding to one such variant failed to localize to oocyte chromosomes or restore cohesion.View evidenceHide evidence

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Claim 7 of 7Not checkedThe story suggests these findings may help understand, assess, or potentially mitigate age-related decline in egg quality and could eventually support strategies to preserve or supplement OMC1 function.View evidenceHide evidence

As statedwithin the next decade

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Oocyte-specific OMC1 is required for maintaining chromosome cohesion through reproductive life

Nature Aging · 2026

Source record (opens in a new tab)

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Papers considered

The selected paper, plus nearby candidates.

Crossref, PubMed · 16 candidate papers

Selected

Oocyte-specific OMC1 is required for maintaining chromosome cohesion through reproductive life

Nature Aging · 2026 · Crossref

Source (opens in a new tab)

And 10 more candidates considered.