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New tool to mutate phages boosts the fight against superbugs (opens in a new tab)

news-medical.net · 2026-09-25

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Claim 1 of 5Not checkedA new tool to mutate bacteriophages is described as a "big leap" for understanding how phages function and for harnessing their potential.View evidenceHide evidence

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Claim 2 of 5Not checkedResearchers at the University of Otago developed a method for genome-wide mutagenesis of bacteriophages using CRISPR-Cas technology.View evidenceHide evidence

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Claim 3 of 5Not checkedThe technique combines transposon insertion sequencing with CRISPR-anti-CRISPR-based selection to identify genes that are essential and non-essential for phage survival.View evidenceHide evidence

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Claim 4 of 5Not checkedThe researchers say the method can also be expanded to add genes directly into phage genomes, including fluorescent markers or potentially additional anti-defence genes to improve therapeutic potential.View evidenceHide evidence

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Claim 5 of 5Not checkedThe story says the new method could help phages combat antimicrobial resistance and could also have applications for sustainable agriculture and biofilm-related infections on prosthetic implants and medical devices.View evidenceHide evidence

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Defining the essential genome of diverse phages with phage Tn-seq

Nature Microbiology · 2026

Source record (opens in a new tab)

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Papers considered

The selected paper, plus nearby candidates.

Crossref, PubMed, Europe PMC · 16 candidate papers

Candidate

Abstract 1335 CRISPR-based bacteriophage engineering reveals essentiality of anti-CRISPR-associated gene

Journal of Biological Chemistry · 2024 · Crossref

Source (opens in a new tab)

And 10 more candidates considered.