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Source study found

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New prime assembly method enables long and precise DNA insertions (opens in a new tab)

news-medical.net · 2026-09-16

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Study found.

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Source paper

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The 2 papers the story cites

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  • The study this story reportspresented as the new finding

    Targeted genomic integration and rearrangement using prime assembly

    Nature · 2026

    Publisher (opens in a new tab)
  • The study this story reportspresented as the new finding

    Targeted genomic integration and rearrangement using prime assembly

    Nature · 2026

    Publisher (opens in a new tab)
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The source study was found, but the study's evidence could not be profiled, so these claims couldn't be checked.

Claim 1 of 5Not checkedA new paper published in Nature describes a genome engineering method called prime assembly that allows long DNA fragments to be stitched into precise and programmable target positions within living cells.View evidenceHide evidence

As statedlong DNA fragments; precise and programmable target positions

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The source study was found, but this claim couldn't be checked against it.

Claim 2 of 5Not checkedThe article says prime assembly builds on prime editing and could allow the development of universal gene therapies that apply to many patients.View evidenceHide evidence

As stateduniversal gene therapies that can apply to many patients

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The source study was found, but this claim couldn't be checked against it.

Claim 3 of 5Not checkedThe story says prime assembly writes new DNA flaps into specific genome locations, uses those flaps to tether matching DNA fragments, and can assemble one or more gene-sized DNA pieces into large permanent edits.View evidenceHide evidence

As statedone or more gene-sized DNA pieces; large permanent edits

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The source study was found, but this claim couldn't be checked against it.

Claim 4 of 5Not checkedThe article claims the method is less likely to cause off-target effects than other gene editing methods because it is based on prime editing.View evidenceHide evidence

As statedmuch less likely to cause off-target effects

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The source study was found, but this claim couldn't be checked against it.

Claim 5 of 5Not checkedThe story says prime assembly may avoid DNA double-strand breaks and double-strand donors, may reduce toxicity and cell stress, and works in nondividing cells.View evidenceHide evidence

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The source study was found, but this claim couldn't be checked against it.

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Targeted genomic integration and rearrangement using prime assembly

Nature · 2026

Source record (opens in a new tab)

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Papers considered

The selected paper, plus nearby candidates.

Crossref, PubMed, Europe PMC · 38 candidate papers

And 32 more candidates considered.