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Source study found

Story checked

New CRISPR proteins expand editing access to heart disease genes (opens in a new tab)

medicalxpress.com · 2026-11-04

Short answerEvidenceSource

Short answer

Not assessed

Check incomplete.

We found a likely source study, but its evidence could not be prepared for claim review. The article's claims remain unverified.

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1
2

NewsLink checks it

Source study identified.

A source study was identified, but the study's evidence could not be prepared for claim assessment. No claim verdicts are available.

View article claims
3

The source study

Sequence Display generates large-scale sequence–activity datasets for reprogramming SlugCas9 toward difficult-to-access PAMs

Nature Communications · 2026
Open source record (opens in a new tab)
Source paper

Source layer

The 2 papers the story cites

Source study separated from background citations.

The research anchor for the report.

  • The study this story reportspresented as the new finding

    Sequence Display generates large-scale sequence–activity datasets for reprogramming SlugCas9 toward difficult-to-access PAMs

    Nature Communications · 2026

    Publisher (opens in a new tab)
  • The study this story reportspresented as the new finding

    Sequence Display generates large-scale sequence–activity datasets for reprogramming SlugCas9 toward difficult-to-access PAMs

    Nature Communications · 2026

    Publisher (opens in a new tab)
Then inspect each claim

Evidence layer

Claim by claim

A source study was identified, but the study's evidence could not be prepared for claim assessment. The claims below have not been assessed.

Claim 1 of 4Not checkedRice University's Han Xiao used his AI-supported Sequence Display technology to expand the targeting abilities of CRISPR/Cas9, and a paper in Nature Communications reported compact Cas9 variants that could efficiently target stretches of DNA previously inaccessible for editing.View evidenceHide evidence

Not checked

A source study was identified, but the evidence comparison for this claim was not completed. No verdict has been assigned.

Claim 2 of 4Not checkedThe researchers evolved several variants of a compact Cas9 and used them in a proof-of-concept study to edit two genes found in coronary heart disease.View evidenceHide evidence

Not checked

A source study was identified, but the evidence comparison for this claim was not completed. No verdict has been assigned.

Claim 3 of 4Not checkedSequence Display let the team evolve a compact Cas9 that could better recognize difficult PAMs already present in the gene, with promising candidates found within a week.View evidenceHide evidence

As statedwithin a week

Not checked

A source study was identified, but the evidence comparison for this claim was not completed. No verdict has been assigned.

Claim 4 of 4Not checkedSlugCas9 struggled with four PAMs of particular interest, and the evolved SlugCas9 could edit specific APOC3 and PCSK9 sites in cultured cells, introducing potentially protective genetic changes linked to a lower risk of coronary heart disease.View evidenceHide evidence

Not checked

A source study was identified, but the evidence comparison for this claim was not completed. No verdict has been assigned.

Finally, the search trail

Method layer

NewsLink found the paper. Tessa takes you deeper.

NewsLink checks the story. Tessa is where you inspect the paper, authors, evidence, and research context.

Open the paper in Tessa

Sequence Display generates large-scale sequence–activity datasets for reprogramming SlugCas9 toward difficult-to-access PAMs

Nature Communications · 2026

Source record (opens in a new tab)

Why this one

Near certain

NewsLink found the paper. Tessa is where you inspect it deeply.

Papers considered

The selected paper, plus nearby candidates.

Crossref, Europe PMC, PubMed · 38 candidate papers

Selected

Sequence Display generates large-scale sequence–activity datasets for reprogramming SlugCas9 toward difficult-to-access PAMs

Nature Communications · 2026 · Crossref

Source (opens in a new tab)

And 32 more candidates considered.