Natural product-derived antifungals against Candida albicans: Chemical diversity and mechanisms of action - ScienceDirect (opens in a new tab)

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Natural product-derived antifungals against Candida albicans: Chemical diversity and mechanisms of action - ScienceDirect

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Natural product-derived antifungals against Candida albicans: Chemical diversity and mechanisms of action

Bioorganic & Medicinal Chemistry · 2026

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Natural product-derived antifungals against Candida albicans: Chemical diversity and mechanisms of action
Bioorganic & Medicinal Chemistry · 2026
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Natural Compounds with Antifungal Properties against Candida albicans and Identification of Hinokitiol as a Promising Antifungal Drug
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Terpenoids from the Liverwort Plagiochila fruticosa and Their Antivirulence Activity against Candida albicans
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Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against Candida Yeast by Inhibition of Lanosterol 14-Alpha Demethylase
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Potential Anti-Candida albicans Mechanism of Trichoderma Acid from Trichoderma spirale
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Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor
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The Effects of Tormentic Acid and Extracts from Callistemon citrinus on Candida albicans and Candida tropicalis Growth and Inhibition of Ergosterol Biosynthesis in Candida albicans
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Biosensor-Enabled Discovery of CaERG6 Inhibitors and Their Antifungal Mode of Action against Candida albicans
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New miconazole-based azoles derived from eugenol show activity against Candida spp. and Cryptococcus gattii by inhibiting the fungal ergosterol biosynthesis
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Targeting Virulence Factors of Candida albicans with Natural Products
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Synthesis and in vitro synergistic antifungal activity of analogues of Panax stipulcanatus saponin against fluconazole-resistant Candida albicans
Carbohydrate Research · 2022
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Anti-Candida albicans Activity of Ononin and Other Secondary Metabolites from Platonia Insignis MART
Metabolites · 2022
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Unraveling the serial glycosylation in the biosynthesis of steroidal saponins in the medicinal plant Paris polyphylla and their antifungal action
Acta Pharmaceutica Sinica B · 2023
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International Journal of Molecular Sciences
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Anti-Candida albicans Effects and Mechanisms of Theasaponin E1 and Assamsaponin A
International Journal of Molecular Sciences · 2023
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Anti-Biofilm Activity of Assamsaponin A, Theasaponin E1, and Theasaponin E2 against Candida albicans
International Journal of Molecular Sciences · 2024
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An unusual 2- O -glyceryl-glycosyl-γ-pyrone from Erigeron annuus (L.) with potential antifungal activity: in-vitro and in-silico study
Natural Product Research · 2025
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Cytotoxic Polyhydroxy-Isoprenoids from Neodidymelliopsis negundinis
Journal of Natural Products · 2024
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Aloin remodels the cell wall of Candida albicans to reduce its hyphal virulence against oral candidiasis
Applied Microbiology and Biotechnology · 2025
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Biosynthesis of the quinovosamycin nucleoside antibiotics diverges from that of tunicamycins by additional sugar processing genes
Bioorganic Chemistry · 2025
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Atomic Insights Into Self‐Assembly of Zingibroside R1 and its Therapeutic Action Against Fungal Diseases
Advanced Materials · 2025
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Intelligent decoding platform for peptide sequences: SERS detection via high affinity self-assembled silver nanoparticles and machine learning analysis
Analytica Chimica Acta · 2025
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Mechanisms of action of antimicrobial peptides ToAP2 and NDBP-5.7 against Candida albicans planktonic and biofilm cells
Scientific Reports · 2020
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WMR Peptide as Antifungal and Antibiofilm against Albicans and Non-Albicans Candida Species: Shreds of Evidence on the Mechanism of Action
International Journal of Molecular Sciences · 2022
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The Membrane Activity of the Amphibian Temporin B Peptide Analog TB_KKG6K Sheds Light on the Mechanism That Kills Candida albicans
mSphere · 2022
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Cecropin D-derived synthetic peptides in the fight against Candida albicans cell filamentation and biofilm formation
Frontiers in Microbiology · 2023
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Fatty acid modification of antimicrobial peptide CGA-N9 and the combats against Candida albicans infection
Biochemical Pharmacology · 2023
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Exploring the Therapeutic Potential of Scorpion-Derived Css54 Peptide Against Candida albicans
Journal of Microbiology · 2024
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In Vitro and In Vivo Anti-Candida albicans Activity of a Scorpion-Derived Peptide
Probiotics and Antimicrobial Proteins · 2025
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Antifungal Efficacy of Ultrashort β-Peptides against Candida Species: Mechanistic Understanding and Therapeutic Implications
ACS Infectious Diseases · 2024
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Antimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms of Candida albicans, Candida parapsilosis and Candidozyma auris
Biomolecules · 2025
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Enniatins from a marine-derived fungus Fusarium sp. inhibit biofilm formation by the pathogenic fungus Candida albicans
Journal of Natural Medicines · 2023
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Cm-p5 Peptide Dimers Inhibit Biofilms of Candida albicans Clinical Isolates, C. parapsilosis and Fluconazole-Resistant Mutants of C. auris
International Journal of Molecular Sciences · 2023
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Reaping the Chemical Diversity of Morinagamyces vermicularis Using Feature-Based Molecular Networking
Journal of Natural Products · 2024
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Vasorelaxant effect of phenylpropanoids: Methyl eugenol and eugenol in human umbilical cord vein
Biomedicine & Pharmacotherapy · 2024
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Effect of Cinnamomum verum leaf essential oil on virulence factors of Candida species and determination of the in-vivo toxicity with Galleria mellonella model
Memórias Do Instituto Oswaldo Cruz · 2020
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Zingerone effect against Candida albicans growth and biofilm production
Journal of Medical Mycology · 2025
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Synthesis of Coumarin and Homoisoflavonoid Derivatives and Analogs: The Search for New Antifungal Agents
Pharmaceuticals · 2022
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Developing Novel Coumarin-Containing Azoles Antifungal Agents by the Scaffold Merging Strategy for Treating Azole-Resistant Candidiasis
Journal of Medicinal Chemistry · 2023
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Unique aminothiazolyl coumarins as potential DNA and membrane disruptors towards Enterococcus faecalis
Bioorganic Chemistry · 2024
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Design, synthesis and characterization of novel 1,5- and 2,5-coumarin-4-yl-methyl regioisomers of 5-pyrazol-3-yl-tetrazoles as promising anticancer and antifungal agents
Journal of Molecular Structure · 2024
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Potent antimicrobial, antifungal, and antioxidant properties of ruthenium, rhodium, and iridium complexes with hydrazinyl-thiazolyl coumarin derivatives targeting Klebsiella pneumoniae, Candida albicans, and Fusarium solani
Journal of Molecular Structure · 2025
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The Effect of Honokiol on Ergosterol Biosynthesis and Vacuole Function inCandida albicans
Journal of Microbiology and Biotechnology · 2020
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Magnolol as a potent antifungal agent inhibits Candida albicans virulence factors via the PKC and Cek1 MAPK signaling pathways
Frontiers in Cellular and Infection Microbiology · 2022
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Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb
Natural Product Research · 2025
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A marine microbiome antifungal targets urgent-threat drug-resistant fungi
Science · 2020
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Antimicrobial Natural Products from Plant Pathogenic Fungi
Molecules · 2023
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Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035
Journal of Fungi · 2024
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Penicitrisochromans A-C, new isochromans from the marine-derived fungus Penicillium citrinum PSU-MF100
Natural Product Research · 2026
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Biosynthesis of the Antifungal Polyhydroxy-Polyketide Acrophialocinol
Organic Letters · 2025
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A semisynthetic borrelidin analogue BN-3b exerts potent antifungal activity against Candida albicans through ROS-mediated oxidative damage
Scientific Reports · 2020
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Penctrimertone, a bioactive citrinin dimer from the endophytic fungus Penicillium sp. T2-11
Fitoterapia · 2020
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A polyene macrolide targeting phospholipids in the fungal cell membrane
Nature · 2025
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A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity
Molecules · 2019
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Antifungal Phenols from Woodfordia uniflora Collected in Oman
Journal of Natural Products · 2020
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Synergistic antifungal effects of curcumin derivatives as fungal biofilm inhibitors with fluconazole
Chemical Biology & Drug Design · 2021
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Potent Antifungal Activity of Penta-O-galloyl-β-d-Glucose against Drug-Resistant Candida albicans, Candida auris, and Other Non-albicans Candida Species
ACS Infectious Diseases · 2023
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Antimicrobial and anti-biofilm properties of oleuropein against Escherichia coli and fluconazole-resistant isolates of Candida albicans and Candida glabrata
BMC Microbiology · 2024
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Natural products and biological activity from actinomycetes associated with Ilex pubescens Hook. & Arn
Natural Product Research · 2026
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n -butanol fraction of Terminalia catappa possesses anti-Candida albicans properties and in vivo action on Tenebrio molitor alternative infection model
Microbial Pathogenesis · 2025
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Activities of Nerol, a natural plant active ingredient, against Candida albicans in vitro and in vivo
Applied Microbiology and Biotechnology · 2020
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Citral derivative activates cell cycle arrest and apoptosis signaling pathways in Candida albicans by generating oxidative stress
Bioorganic Chemistry · 2021
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Discovery of New Antimicrobial Metabolites in the Coculture of Medicinal Mushrooms
Journal of Agricultural and Food Chemistry · 2024
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Investigation of bioactive metabolites produced by the endophytic fungus Aspergillus iranicus from Houttuynia cordata Thunb
Natural Product Research · 2026
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Cell wall associated proteins involved in filamentation with impact on the virulence of Candida albicans
Microbiological Research · 2022
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The Role of Sfp1 in Candida albicans Cell Wall Maintenance
Journal of Fungi · 2022
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Journal of Microbiology and Biotechnology
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Sequence of occurring damages in yeast plasma membrane during dehydration and rehydration: Mechanisms of cell death
Biochimica Et Biophysica Acta (BBA) - Biomembranes · 2007
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Dodecapeptides derived from human cathelicidin with potent activity against carbapenem-resistant Acinetobacter baumannii
European Journal of Medicinal Chemistry · 2025
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Membrane of Candida albicans as a target of berberine
BMC Complementary and Alternative Medicine · 2017
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Discovery of novel phenylhydrazone-based oxindole-thiolazoles as potent antibacterial agents toward Pseudomonas aeruginosa
European Journal of Medicinal Chemistry · 2022
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2,3-Dideoxyglucosides of selected terpene phenols and alcohols as potent antifungal compounds
Food Chemistry · 2016
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Insights into the role of sterol metabolism in antifungal drug resistance: a mini-review
Frontiers in Microbiology · 2024
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Molecular Mechanisms of Pathogenic Fungal Virulence Regulation by Cell Membrane Phospholipids
Journal of Fungi · 2025
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Candida albicans the chameleon: transitions and interactions between multiple phenotypic states confer phenotypic plasticity
Current Opinion in Microbiology · 2015
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From Jekyll to Hyde: The Yeast–Hyphal Transition of Candida albicans
Pathogens · 2021
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Conserved and Divergent Functions of the cAMP/PKA Signaling Pathway in Candida albicans and Candida tropicalis
Journal of Fungi · 2018
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The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition of Candida albicans
Current Clinical Microbiology Reports · 2023
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Host–pathogen interactions and virulence-associated genes during Candida albicans oral infections
International Journal of Medical Microbiology · 2011
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The Candida albicans biofilm gene circuit modulated at the chromatin level by a recent molecular histone innovation
PLOS Biology · 2019
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Marine natural products and their synthetic analogs as promising antibiofilm agents for antibiotics discovery and development
European Journal of Medicinal Chemistry · 2022
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Hydrolytic enzymes as virulence factors of Candida albicans
Mycoses · 2005
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Sap6, a secreted aspartyl proteinase, participates in maintenance the cell surface integrity of Candida albicans
Journal of Biomedical Science · 2013
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Differential Expression ofCandida albicansSecreted Aspartyl Proteinase and Phospholipase B Genes in Humans Correlates with Active Oral and Vaginal Infections
The Journal of Infectious Diseases · 2003
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The Role of Secreted Aspartyl Proteinases inCandida albicansKeratitis
Investigative Opthalmology & Visual Science · 2007
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Bacterial lipolysis of immune-activating ligands promotes evasion of innate defenses
Proceedings of the National Academy of Sciences · 2019
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Halofantrine Hydrochloride Acts as an Antioxidant Ability Inhibitor That Enhances Oxidative Stress Damage to Candida albicans
Antioxidants · 2024
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Vacuole and mitochondria patch (vCLAMP) and ER-mitochondria encounter structure (ERMES) maintain cell survival by protecting mitochondrial functions in Candida albicans
Biochemical and Biophysical Research Communications · 2022
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Functional connections between cell cycle and proteostasis in the regulation of Candida albicans morphogenesis
Cell Reports · 2021
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Metal ions overloading and cell death
Cell Biology and Toxicology · 2024
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Claim 1 of 5Not checkedThe review systematically summarizes recent advances in natural products and derivatives with activity against Candida albicans from 2020 to the first half of 2025.View evidenceHide evidence

As stated2020 to first half of 2025

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