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Maladaptive brain-state locking framework redefines chronic brain disorders (opens in a new tab)
news-medical.net · 2026-10-21
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Maladaptive brain-state locking framework redefines chronic brain disorders
news-medical.net · 2026-10-21
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Maladaptive Brain-state Locking as a Lifespan Framework for Neurodevelopmental, Psychiatric, and Neurodegenerative Disorders: A Hypothesis
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Claim 1 of 6Not checkedThe article proposes maladaptive brain-state locking (MBSL) as a lifespan framework for neurodevelopmental, psychiatric, and neurodegenerative disorders.View evidenceHide evidence
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Claim 2 of 6Not checkedMBSL is defined as a failure of adaptive state-transition or recovery dynamics in which a maladaptive state becomes insufficiently reversible.View evidenceHide evidence
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Claim 3 of 6Not checkedThe article says MBSL differs from persistence alone, because a state maintained by a continuing pathological driver does not count as locking.View evidenceHide evidence
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Claim 4 of 6Not checkedCandidate features of MBSL include abnormal persistence, impaired transition toward adaptive states, delayed recovery after perturbation removal, and history-dependent loss of flexibility.View evidenceHide evidence
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Claim 5 of 6Not checkedThe article states that existing evidence is compatible with components of the hypothesis, but direct demonstration would require longitudinal or perturbational evidence of impaired recovery.View evidenceHide evidence
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Claim 6 of 6Not checkedIt also notes key limitations, including etiological heterogeneity, nonspecific biomarkers, unresolved causality, and the absence of a single validated biomarker.View evidenceHide evidence
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Maladaptive Brain-state Locking as a Lifespan Framework for Neurodevelopmental, Psychiatric, and Neurodegenerative Disorders: A Hypothesis
Exploratory Research and Hypothesis in Medicine · 2026
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Crossref, PubMed, Europe PMC · 39 candidate papers
Maladaptive Brain-state Locking as a Lifespan Framework for Neurodevelopmental, Psychiatric, and Neurodegenerative Disorders: A Hypothesis
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And 33 more candidates considered.