Source study found
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Low vitamin B12 is linked to heart disease. Supplements tell a different story (opens in a new tab)
news-medical.net · 2026-10-27
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We found a likely source study, but its evidence could not be prepared for claim review. The article's claims remain unverified.
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The story
Low vitamin B12 is linked to heart disease. Supplements tell a different story
news-medical.net · 2026-10-27
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Source study identified.
A source study was identified, but the study's evidence could not be prepared for claim assessment. No claim verdicts are available.
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Vitamin B12 and cardiovascular health: mechanisms, clinical evidence, and future directions
Evidence layer
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A source study was identified, but the study's evidence could not be prepared for claim assessment. The claims below have not been assessed.
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Claim 1 of 8Not checkedLow vitamin B12 concentrations are associated with cardiovascular disease.View evidenceHide evidence
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A source study was identified, but the evidence comparison for this claim was not completed. No verdict has been assigned.
Claim 2 of 8Not checkedSupplementation has not consistently prevented major cardiovascular events.View evidenceHide evidence
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A source study was identified, but the evidence comparison for this claim was not completed. No verdict has been assigned.
Claim 3 of 8Not checkedThe strongest evidence of a possible clinical benefit concerns combined B-vitamin therapy for stroke prevention, particularly in populations without mandatory folic acid fortification.View evidenceHide evidence
As statedapproximately 10 percent relative reduction in stroke incidence overall; 30 to 35 percent in a subgroup without folic acid fortification
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A source study was identified, but the evidence comparison for this claim was not completed. No verdict has been assigned.
Claim 4 of 8Not checkedThe review draws on laboratory studies, large population studies, and clinical trials to evaluate the role of vitamin B12 in cardiovascular health.View evidenceHide evidence
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A source study was identified, but the evidence comparison for this claim was not completed. No verdict has been assigned.
Claim 5 of 8Not checkedThe review cites prior observational studies linking low vitamin B12 levels with stroke, heart failure, markers of arrhythmia susceptibility, atherosclerosis, and death.View evidenceHide evidence
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A source study was identified, but the evidence comparison for this claim was not completed. No verdict has been assigned.
Claim 6 of 8Not checkedRandomized trials such as NORVIT and HOPE-2 lowered homocysteine but did not consistently reduce heart attacks, cardiovascular deaths, or total vascular events; HOPE-2 reported fewer strokes and NORVIT hinted at possible harm with the three-vitamin combination.View evidenceHide evidence
As statedabout 27 percent homocysteine reduction in NORVIT
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A source study was identified, but the evidence comparison for this claim was not completed. No verdict has been assigned.
Claim 7 of 8Not checkedA Cochrane review of more than 71,000 participants found no meaningful benefit for coronary outcomes.View evidenceHide evidence
As statedmore than 71,000 participants
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A source study was identified, but the evidence comparison for this claim was not completed. No verdict has been assigned.
Claim 8 of 8Not checkedThe article says older adults, vegetarians and vegans, post-bariatric surgery patients, dialysis patients, and pregnant people are among groups highlighted as higher risk or needing monitoring for B12 deficiency.View evidenceHide evidence
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A source study was identified, but the evidence comparison for this claim was not completed. No verdict has been assigned.
Method layer
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Open the paper in Tessa
Vitamin B12 and cardiovascular health: mechanisms, clinical evidence, and future directions
Nutrition Journal · 2026
Why this one
Near certain
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Papers considered
The selected paper, plus nearby candidates.
Crossref, PubMed, Europe PMC · 16 candidate papers
Vitamin B12 and cardiovascular health: mechanisms, clinical evidence, and future directions
Nutrition Journal · 2026 · Crossref
Homocysteine and related B-vitamins throughout our International Conferences: a historical perspective.
Biochimie · 2026 · PubMed, Europe PMC
The role of Homocysteine, Folic Acid, Vitamin B6, Vitamin B12 in development of coronary heart disease in Lebanon. (c1999)
Crossref
Sarcopenia and Vitamin B12: Where Do We Stand?
2026 · Europe PMC
Vitamin B12, Homocysteine and Cognitive Impairment in Elderly Patients with Type 2 Diabetes.
Journal of Clinical Medicine · 2026 · PubMed, Europe PMC
B vitamin therapy for homocysteine: renal function and vitamin B12 determine cardiovascular outcomes
Clinical Chemistry and Laboratory Medicine · 2013 · Crossref
And 10 more candidates considered.