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Local DNA motion remains nearly constant during cell interphase (opens in a new tab)

news-medical.net · 2026-10-14

Short answerEvidenceSource

Short answer

Mixed

Mixed.

The claims we could check match the study, but some claims were not covered by the evidence reviewed.

  • 3 supported
  • 2 not covered

Checked against the study summary. The full text wasn't available, so some details couldn't be settled either way.

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1
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NewsLink checks it

Mixed

Every claim we could check holds up. Three of five claims match the study. This overall rating is based only on the claims we could check. Two claims the study doesn't address.

  • 3 supported
  • 2 not covered
Open claim evidence
3
Source paper

Source layer

The 3 papers the story cites

Source study separated from background citations.

The research anchor for the report.

Then inspect each claim

Evidence layer

Claim by claim

Each claim gets a verdict. Expand it to see the evidence directly below.

5 claims in this story

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Claim 1 of 5Not coveredH3.3-HaloTag nucleosomes showed greater motion than bulk H2B-HaloTag nucleosomes, but that higher motion also remained nearly constant throughout interphase.View evidenceHide evidence

As statedgreater motion

Why this verdict

The abstract-level profile supports that H3.3-Halo-labeled nucleosomes showed near-constant motion throughout interphase. However, it explicitly lacks quantitative comparisons to bulk H2B-HaloTag nucleosomes, so the story’s added statement that H3.3-Halo nucleosomes showed greater motion than H2B-HaloTag nucleosomes is not verifiable from the supplied abstract-depth evidence.

1

Study evidence

H3.3-Halo–labeled nucleosomes, enriched in Hi-C A compartments (euchromatin), exhibited near-constant average local motion throughout interphase (G1, S, G2).

“Consistently, H3.3-Halo-labeled nucleosomes, which are enriched in Hi-C A compartments (euchromatin), also showed near-constant motion throughout interphase.”
Claim 2 of 5Not coveredThe article says increased DNA motion after DNA damage may help recruit DNA repair factors.View evidenceHide evidence

As statedincreased DNA motion

Why this verdict

The profile supports that DNA damage increased local nucleosome motion and that the authors discuss transient chromatin-motion changes as potentially helping cells perform ad hoc tasks. But the specific statement that increased motion may help recruit DNA repair factors is not available in the supplied abstract-depth profile, so this hedged mechanistic interpretation cannot be verified here.

1

Study evidence

Replication stress increased local nucleosome motion throughout interphase in living human cells (HeLa and HCT116) as measured by single-nucleosome imaging and motion analysis.

“Local nucleosome motion also increased following cellular perturbations, such as replication stress or DNA damage.”
Claim 3 of 5SupportedA research team led by Professor Kazuhiro Maeshima showed that average local DNA motion remains nearly constant throughout interphase in living human cells.View evidenceHide evidence

As statednearly constant

Why this verdict

The abstract-level profile supports the central finding that local nucleosome/chromatin motion remained similar on average across G1/S/G2 in living human cells using H2B-HaloTag and Fucci reporters. The story’s wording as a headline-level statement is broadly consistent, though the abstract evidence is limited to reported HeLa and HCT116 cell experiments and does not provide quantitative detail.

1

Study evidence

Average local nucleosome motion remained similar on average throughout interphase (G1, S, G2) in asynchronous HeLa and HCT116 cells imaged via H2B-HaloTag with Fucci reporters.

“we combined single-nucleosome imaging with Fucci cell-cycle probes to test this finding in asynchronous living human cells”
Claim 4 of 5SupportedThe motion is not just constant; it can increase in response to transcription inhibition, replication stress, and DNA damage.View evidenceHide evidence

As statedincrease

Why this verdict

The paper profile states that transcription inhibition increased nucleosome motion throughout interphase and that replication stress or DNA damage also increased local nucleosome motion. The story’s claim of increased motion under these perturbations matches the abstract-level evidence, although details such as agents, doses, timing, and effect sizes are unavailable at this depth.

1

Study evidence

Transcription inhibition increased nucleosome motion throughout interphase.

“Transcription inhibition increased nucleosome motion throughout interphase.”
2

Study evidence

Replication stress increased local nucleosome motion throughout interphase in living human cells (HeLa and HCT116) as measured by single-nucleosome imaging and motion analysis.

“Local nucleosome motion also increased following cellular perturbations, such as replication stress or DNA damage.”
Claim 5 of 5SupportedThe present study tested whether the same behavior is seen in asynchronously growing cells without drug-induced synchronization, using single-nucleosome imaging and Fucci probes.View evidenceHide evidence

Why this verdict

The abstract-level profile explicitly says the study combined single-nucleosome imaging with Fucci cell-cycle probes to test the prior constant-motion finding in asynchronous living human cells. That supports the story’s framing that the study examined asynchronously growing cells rather than relying on drug-induced synchronization.

1

Study evidence

Average local nucleosome motion remained similar on average throughout interphase (G1, S, G2) in asynchronous HeLa and HCT116 cells imaged via H2B-HaloTag with Fucci reporters.

“we combined single-nucleosome imaging with Fucci cell-cycle probes to test this finding in asynchronous living human cells”
Then look for missing context

Context layer

What the story left out

Important study details the story did not include.

  • For perturbation experiments, the abstract does not specify transcription-inhibition, replication-stress, or DNA-damage agents, doses, timing, or controls.

    The story presents the perturbation increases but does not note the absence of protocol and control details in the abstract-level evidence.

    From transcription inhibition with live-cell single-nucleosome imaging; perturbation experiment (replication stress or DNA da

5 things the story did carry across
  • Primary finding: average local nucleosome/chromatin motion remained similar across interphase in asynchronous living human cells using H2B-HaloTag single-nucleosome imaging and Fucci phase staging.
  • Study context: the work extends prior synchronized-cell observations to asynchronously growing cells without relying on drug-induced synchronization.
  • H3.3-Halo-labeled, euchromatin/A-compartment-enriched nucleosomes also showed near-constant motion throughout interphase.
  • Transcription inhibition increased nucleosome motion throughout interphase.
  • Replication stress and DNA damage increased local nucleosome motion.
Then read the study layer

Study layer

Study at a glance

Scan the study first. Expand only the parts you want to inspect.

Pieces of work

4

Evidence read

study summary

Lead result

human in vivo

1Lead resulthuman in vivoTest whether average local nucleosome/chromatin motion remains nearly constant across interphase (G1/S/G2) in asynchronous living human cells using single-nucleosome imaging with Fucci cell-cycle staging.Live-cell single-nucleosome imaging with Fucci-based cell-cycle stagingExpand

In plain English

Using live-cell single-nucleosome imaging with Fucci cell-cycle reporters in asynchronous HeLa and HCT116 cells expressing H2B-HaloTag, average local nucleosome motion on a subsecond timescale remained similar across interphase (G1, S, G2). H3.3-Halo-labeled nucleosomes (enriched in Hi-C A compartments/euchromatin) showed a similar near-constant motion profile. Perturbations — transcription inhibition, replication stress, and DNA damage — increased local nucleosome motion.

Key findings

  • Average local nucleosome motion remained similar on average throughout interphase (G1, S, G2) in asynchronous HeLa and HCT116 cells imaged via H2B-HaloTag with Fucci reporters.
  • H3.3-Halo-labeled nucleosomes, which are enriched in Hi-C A compartments (euchromatin), also showed near-constant motion throughout interphase.
“we combined single-nucleosome imaging with Fucci cell-cycle probes to test this finding in asynchronous living human cells”
What this piece can’t prove

2 further details could not be confirmed from the summary.

2human in vivoAssess whether euchromatin-enriched, H3.3-labeled nucleosomes also show near-constant motion across interphase.Live-cell single-nucleosome imaging of H3.3-Halo across interphaseExpand

In plain English

Using live-cell single-nucleosome imaging of H3.3-Halo–labeled nucleosomes (euchromatin/A-compartment–enriched), the authors report that local nucleosome motion remained near-constant on average across interphase (G1, S, G2).

Key findings

  • H3.3-Halo–labeled nucleosomes, enriched in Hi-C A compartments (euchromatin), exhibited near-constant average local motion throughout interphase (G1, S, G2).
“Consistently, H3.3-Halo-labeled nucleosomes, which are enriched in Hi-C A compartments (euchromatin), also showed near-constant motion throughout interphase.”
What this piece can’t prove
  • Unclear whether the same experimental settings (cell lines, imaging frame rate, tracking parameters) were used for H3.3-Halo experiments as for H2B-Halo experiments.

3 further details could not be confirmed from the summary.

3human in vivoDetermine how transcription inhibition affects local nucleosome motion across interphase.transcription inhibition with live-cell single-nucleosome imagingExpand

In plain English

The paper reports that applying transcription inhibition increased average local nucleosome motion throughout interphase in living human cells imaged by single-nucleosome tracking; details of the inhibition (identity, dose, timing) and quantitative effect size are not provided in the abstract.

Key findings

  • Transcription inhibition increased nucleosome motion throughout interphase.
“Transcription inhibition increased nucleosome motion throughout interphase.”
What this piece can’t prove

4 further details could not be confirmed from the summary.

4human in vivoDetermine how cellular perturbations (replication stress, DNA damage) affect local nucleosome motion across interphase.perturbation experiment (replication stress or DNA damage vs control) with live single-nucleosome trackingExpand

In plain English

In live asynchronous human cells (HeLa and HCT116) imaged with single-nucleosome tracking, inducing replication stress or DNA damage increased average local nucleosome motion throughout interphase compared with unperturbed controls.

Key findings

  • Replication stress increased local nucleosome motion throughout interphase in living human cells (HeLa and HCT116) as measured by single-nucleosome imaging and motion analysis.
  • DNA damage increased local nucleosome motion throughout interphase in living human cells as measured by single-nucleosome imaging and motion analysis.
“Local nucleosome motion also increased following cellular perturbations, such as replication stress or DNA damage.”
What this piece can’t prove
  • Summary based solely on the abstract; full methodological and quantitative details (agents, doses, timing, statistical tests, effect magnitudes) are not available here.
  • The abstract does not report numerical effect sizes or significance levels for the increases in nucleosome motion.

1 further detail could not be confirmed from the summary.

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Papers considered

The selected paper, plus nearby candidates.

Crossref, PubMed, Europe PMC · 37 candidate papers

Candidate

Author response for "Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent through Chemical Library Screening"

2026 · Crossref

Source (opens in a new tab)

And 31 more candidates considered.