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IBD not linked to risk of hypertensive disorders of pregnancy overall (opens in a new tab)

medicalxpress.com · 2026-09-24

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IBD not linked to risk of hypertensive disorders of pregnancy overall

medicalxpress.com · 2026-09-24

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The source study

The Risk of Hypertensive Disorders of Pregnancy in Inflammatory Bowel Disease

The American Journal of Gastroenterology · 2026

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4 claims in this story

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Claim 1 of 4SupportedInflammatory bowel disease (IBD) is not associated with an increased risk of hypertensive disorders of pregnancy overall.View evidenceHide evidence

Why this verdict

The abstract-level profile reports that the primary composite outcome, any hypertensive disorder of pregnancy including gestational hypertension or pre-eclampsia, was not statistically significantly associated with IBD: adjusted odds ratio 1.21, 95% CI 0.81–1.82, P=0.35. The headline claim matches the paper’s primary finding, though more precise wording would be 'no statistically significant association' rather than absolute absence of association.

Study evidence

In this single-center EHR cohort, IBD was not associated with the primary composite outcome of any hypertensive disorder of pregnancy (gestational hypertension or pre-eclampsia).aOR 1.21 (95% CI 0.81–1.82), P = 0.35

“We performed a single-center cohort study using electronic health records of singleton pregnancies delivered 1998-2016.”

Claim 2 of 4SupportedIBD is associated with an increased risk of preeclampsia, but not gestational hypertension.View evidenceHide evidence

As statedadjusted odds ratio, 1.65 for preeclampsia

Why this verdict

The profile reports that IBD was associated with increased adjusted odds of pre-eclampsia, aOR 1.65, 95% CI 1.02–2.68, and was not associated with gestational hypertension, aOR 0.82, 95% CI 0.42–1.57. The stated magnitude for pre-eclampsia matches the abstract-level evidence. This was a secondary outcome, and the confidence interval is close to 1, but the claim is framed associationally rather than causally.

Study evidence

IBD was associated with increased odds of pre-eclampsia.aOR 1.65 (95% CI 1.02–2.68)

“Secondary outcomes included gestational hypertension, pre-eclampsia, preterm delivery, gestational diabetes, severe perineal laceration, and small or large for gestational age birth weight.”

Claim 3 of 4SupportedIn the study, IBD was also associated with preterm delivery, small for gestational age, and cesarean delivery, but not with other secondary outcomes.View evidenceHide evidence

As statedadjusted odds ratios, 1.87, 1.72 and 1.72, respectively

Why this verdict

The profile reports increased adjusted odds for preterm delivery, aOR 1.87, small for gestational age, aOR 1.72, and cesarean delivery, aOR 1.72, and states that other prespecified secondary outcomes reported in the abstract were not associated with IBD. The claim accurately reflects these secondary-outcome findings and magnitudes.

Study evidence

IBD was associated with increased odds of pre-eclampsia.aOR 1.65 (95% CI 1.02–2.68)

“Secondary outcomes included gestational hypertension, pre-eclampsia, preterm delivery, gestational diabetes, severe perineal laceration, and small or large for gestational age birth weight.”

Claim 4 of 4SupportedThe authors describe the study as a single-center cohort of singleton pregnancies delivered from 1998 to 2016, using electronic health records.View evidenceHide evidence

As stated364 pregnancies with IBD and 45,048 pregnancies without IBD

Why this verdict

The profile describes the study as a single-center retrospective cohort using electronic health records of singleton pregnancies delivered from 1998–2016, with 364 IBD pregnancies and 45,048 non-IBD pregnancies. The claim matches the abstract methods and reported sample sizes.

Study evidence

“We performed a single-center cohort study using electronic health records of singleton pregnancies delivered 1998-2016.”

Study evidence

IBD was associated with increased odds of pre-eclampsia.aOR 1.65 (95% CI 1.02–2.68)

“Secondary outcomes included gestational hypertension, pre-eclampsia, preterm delivery, gestational diabetes, severe perineal laceration, and small or large for gestational age birth weight.”

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What the story left out

Important study details the story did not include.

Analytic approach: generalized estimating equations with adjustment for age, first-trimester BMI and blood pressure, insurance, race, and parity.
The story mentions electronic health records and the cohort design, but the supplied presentation does not indicate that the model used GEE or list the covariate adjustment set.
From Single-center retrospective EHR cohort; Retrospective EHR cohort; secondary outcome GEE logistic regression
Important limitation: multiple secondary outcomes were assessed, and the abstract does not report correction for multiple comparisons; secondary findings such as pre-eclampsia should be interpreted cautiously.
The story reports the secondary associations but does not mention multiplicity or the secondary nature of these analyses as a caveat.
From Retrospective EHR cohort; secondary outcome GEE logistic regression

6 things the story did carry across

Primary outcome: IBD was not statistically significantly associated with any hypertensive disorder of pregnancy overall, defined as gestational hypertension or pre-eclampsia, with aOR 1.21, 95% CI 0.81–1.82.
Secondary hypertensive subtypes: IBD was associated with increased adjusted odds of pre-eclampsia but not gestational hypertension.
Other secondary outcomes: IBD was associated with preterm delivery, small for gestational age birth weight, and cesarean delivery, but not with other listed secondary outcomes in the abstract.
Study design and population: single-center retrospective EHR cohort of singleton deliveries from 1998–2016, including 364 pregnancies with IBD and 45,048 without IBD.
Important limitation: the study was single-center and retrospective, which may limit generalizability and increase susceptibility to EHR ascertainment issues.
Precision limitation: the IBD group was relatively small compared with the non-IBD group, potentially affecting precision for some outcomes.

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study summary

Lead result

secondary data

1Lead resultsecondary dataEstimate whether inflammatory bowel disease (IBD) is associated with hypertensive disorders of pregnancy overall (composite outcome: gestational hypertension or pre-eclampsia) in a single-center EHR pregnancy cohort.Single-center retrospective EHR cohortExpand

In plain English

Single-center retrospective EHR cohort of singleton deliveries (1998–2016) estimated the association between maternal IBD and any hypertensive disorder of pregnancy (composite of gestational hypertension or pre-eclampsia) using GEE models adjusted for age, first-trimester BMI and blood pressure, insurance, race, and parity. The adjusted odds ratio for the primary composite outcome was 1.21 (95% CI 0.81–1.82; P = 0.35), indicating no statistically significant association in this cohort.

Key findings

In this single-center EHR cohort, IBD was not associated with the primary composite outcome of any hypertensive disorder of pregnancy (gestational hypertension or pre-eclampsia).aOR 1.21 (95% CI 0.81–1.82), P = 0.35

“We performed a single-center cohort study using electronic health records of singleton pregnancies delivered 1998-2016.”

2secondary dataEvaluate associations between IBD and specific adverse pregnancy outcomes, including pre-eclampsia vs gestational hypertension separately and other obstetric/neonatal outcomes (e.g., preterm delivery, SGA, cesarean delivery).Retrospective EHR cohort; secondary outcome GEE logistic regressionExpand

In plain English

Single-center retrospective EHR cohort (singleton deliveries 1998–2016) analyzing associations between maternal IBD and multiple secondary obstetric and neonatal outcomes using GEE logistic regression adjusted for age, first-trimester BMI and blood pressure, insurance, race, and parity. Among 364 IBD pregnancies and 45,048 non-IBD pregnancies, IBD was associated with higher adjusted odds of pre-eclampsia, preterm delivery, small for gestational age birth weight, and cesarean delivery, but not with gestational hypertension or other listed secondary outcomes.

Key findings

IBD was associated with increased odds of pre-eclampsia.aOR 1.65 (95% CI 1.02–2.68)
IBD was not associated with gestational hypertension.aOR 0.82 (95% CI 0.42–1.57)

“Secondary outcomes included gestational hypertension, pre-eclampsia, preterm delivery, gestational diabetes, severe perineal laceration, and small or large for gestational age birth weight.”

What this piece can’t prove

Single-center, retrospective EHR cohort which may limit generalizability.
Relatively small number of IBD pregnancies (n=364) compared with non-IBD pregnancies, potentially affecting precision for some outcomes.
Multiple secondary outcomes were assessed; abstract does not report correction for multiple comparisons.

1 further detail could not be confirmed from the summary.

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