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How loss of the critical tumor suppressor p53 enables mutant cells to expand through normal tissue (opens in a new tab)
medicalxpress.com · 2026-10-01
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How loss of the critical tumor suppressor p53 enables mutant cells to expand through normal tissue
medicalxpress.com · 2026-10-01
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This story isn't reporting one study.
The article covers a research area rather than reporting a specific new paper, so there is no single study to check it against.
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The article covers a research area rather than reporting a specific new paper, so there is no single study to check it against.
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Loss of the tumor suppressor p53 generates a signaling gradient that drives epithelial clonal expansion
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Claim 1 of 5Not checkedLoss of p53 can allow populations of mutant cells to expand through normal tissue, and the mechanism remains unclear.View evidenceHide evidence
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Claim 2 of 5Not checkedResearchers at Mount Sinai found that loss of p53 reorganizes Wnt signaling into a radial gradient, with lower activity near the edge of a mutant clone and higher activity toward its center.View evidenceHide evidence
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Claim 3 of 5Not checkedIn mouse skin, clonal expansion of p53-deficient epithelial cells was driven primarily by a shift in cell fate, with mutant progenitor cells more likely to self-renew and less likely to differentiate.View evidenceHide evidence
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Claim 4 of 5Not checkedThe researchers identified three genes directly regulated by p53—Sfrp1, Lrp1 and Usp22—that normally help restrain Wnt signaling.View evidenceHide evidence
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Claim 5 of 5Not checkedClones with a persistent Wnt gradient expanded efficiently, whereas clones with more uniformly elevated Wnt activity expanded less effectively even when overall Wnt activity was higher.View evidenceHide evidence
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Nearby research
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