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Heart disease and depression may affect brain aging in an unexpected way (opens in a new tab)
news-medical.net · 2026-11-03
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Heart disease and depression may affect brain aging in an unexpected way
news-medical.net · 2026-11-03
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Source study identified.
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The association between cardiovascular disease and cognitive decline varies by long-term depressive symptom trajectories in older adults
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Claim 1 of 7Not checkedA 14-year study of more than 5,400 adults found a complex relationship between cardiovascular health, mental health, and changes in memory and thinking.View evidenceHide evidence
As statedmore than 5,400 adults; 14-year study
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Claim 2 of 7Not checkedResearchers in Scientific Reports investigated whether long-term depressive symptom trajectories modify the association between cardiovascular disease (CVD) and cognitive decline among middle-aged and older adults.View evidenceHide evidence
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Claim 3 of 7Not checkedThe study used English Longitudinal Study of Ageing data from 2004–2005 to 2018–2019 and analyzed 5,423 adults aged 50 and older after exclusions.View evidenceHide evidence
As stated5,423 participants
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Claim 4 of 7Not checkedBaseline CVD was associated with faster decline in global cognition, memory, semantic fluency, and orientation.View evidenceHide evidence
As statedadditional annual decline of 0.045 SD in global cognition; 0.034 SD/year in semantic fluency; 0.034 SD/year in memory; 0.018 SD/year in orientation
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Claim 5 of 7Not checkedLong-term depressive symptom burden was also associated with poorer baseline cognitive performance and faster cognitive decline over follow-up.View evidenceHide evidence
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Claim 6 of 7Not checkedThe extra cognitive decline associated with CVD was more pronounced in the low-stable depressive symptoms group than in the moderate-stable or high-stable groups, indicating an interaction between depressive symptom trajectories and CVD.View evidenceHide evidence
As statedadditional annual decline of 0.051 SD in global cognition in the low-stable group; interaction coefficients β = 0.031 and β = 0.059
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Claim 7 of 7Not checkedThe article says the observational design cannot establish causation and notes limitations including lack of data on CVD severity, depression treatment, and brain imaging.View evidenceHide evidence
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The association between cardiovascular disease and cognitive decline varies by long-term depressive symptom trajectories in older adults
Scientific Reports · 2026
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Papers considered
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