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First successful primate transplant of human pituitary tissue boosts cortisol levels (opens in a new tab)
medicalxpress.com · 2026-10-01
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First successful primate transplant of human pituitary tissue boosts cortisol levels
medicalxpress.com · 2026-10-01
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Open claim evidenceThe source study
Functional analysis of adrenocorticotropic-hormone–producing pituitary cells derived from human pluripotent stem cells in murine and primate models of hypopituitarism
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Claim 1 of 6Not checkedResearchers in Japan transplanted pituitary tissue grown from human stem cells into a primate whose pituitary gland had been surgically removed, restoring critical hormone signals.View evidenceHide evidence
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Claim 2 of 6Not checkedThe article says this is the first time lab-grown human pituitary cells have been shown to work and survive after transplantation into a primate.View evidenceHide evidence
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Claim 3 of 6Not checkedThe same method was first tested in mice whose pituitary glands were removed, where the transplanted organoids produced ACTH for more than six months and extended lifespan compared with mice that did not receive the transplant.View evidenceHide evidence
As statedmore than six months
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Claim 4 of 6Not checkedIn a macaque monkey, the transplanted tissue worked for six weeks and elevated ACTH and cortisol levels in the blood, while significant weight loss from the hormone deficiency slowed during that period.View evidenceHide evidence
As statedsix weeks
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Claim 5 of 6Not checkedThree months later, tissue samples still showed surviving transplanted cells despite immune rejection, and no stray organoid tissue was found in the lungs or liver.View evidenceHide evidence
As statedthree months later
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Claim 6 of 6Not checkedThe researchers said they tested the approach in a single primate and plan further studies to improve durability and safer immune-suppressing methods.View evidenceHide evidence
As stateda single primate
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Functional analysis of adrenocorticotropic-hormone–producing pituitary cells derived from human pluripotent stem cells in murine and primate models of hypopituitarism
Stem Cell Research & Therapy · 2026
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Papers considered
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Crossref, PubMed, Europe PMC · 16 candidate papers
Functional analysis of adrenocorticotropic-hormone–producing pituitary cells derived from human pluripotent stem cells in murine and primate models of hypopituitarism
Stem Cell Research & Therapy · 2026 · Crossref
Ceritinib inhibits growth and ACTH production of PitNETs: Insights from patient-derived organoids.
Pharmacological Research · 2025 · PubMed, Europe PMC
2 TECHNIQUES AND EFFECTS OF HYPOPHYSECTOMY, PITUITARY STALK SECTION, AND PITUITARY TRANSPLANTATION IN MAN
Anterior Pituitary · 1966 · Crossref
Development and application of organoid technology in pituitary neuroendocrine tumor research.
2026 · Europe PMC
Pituitary organoids as models for congenital pituitary deficiencies.
Presse Medicale (Paris, France : 1983) · 2025 · PubMed
1 THE TECHNIQUES AND EFFECTS OF HYPOPHYSECTOMY, PITUITARY STALK SECTION AND PITUITARY TRANSPLANTATION IN EXPERIMENTAL ANIMALS
Anterior Pituitary · 1966 · Crossref
And 10 more candidates considered.