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First human endothelial cell atlas maps how blood vessels age (opens in a new tab)
news-medical.net · 2026-10-27
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First human endothelial cell atlas maps how blood vessels age
news-medical.net · 2026-10-27
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Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis
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Claim 1 of 6Not checkedAn international team led by Laura de Rooij created the Human Aging Endothelial Cell Atlas, described as the first comprehensive atlas of vascular aging.View evidenceHide evidence
As statedfirst comprehensive atlas
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Claim 2 of 6Not checkedBy analyzing gene activity data from more than 375,000 human cells across 290 samples and 12 tissues, the scientists report that aging affects different parts of the vascular system in distinct ways.View evidenceHide evidence
As statedmore than 375,000 human cells; 290 samples; 12 tissues
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Claim 3 of 6Not checkedIn older individuals, venous endothelial cells showed reduced activity of several genes involved in vessel formation, which the article says could help explain reduced vascular renewal with age, though repair capacity was not directly measured.View evidenceHide evidence
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Claim 4 of 6Not checkedAcross multiple tissues, the researchers observed increased activity of genes associated with inflammation and cellular senescence.View evidenceHide evidence
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Claim 5 of 6Not checkedThe atlas showed age-related changes in genes involved in mechanosensing, and experiments in human skin found YAP more frequently inside endothelial-cell nuclei from older donors.View evidenceHide evidence
As statedmore frequently
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Claim 6 of 6Not checkedComparisons with laboratory-grown endothelial cells and mouse models of accelerated aging supported a connection between p21-associated genes and cellular senescence, but the article says these genes cannot reliably distinguish permanently senescent cells from other stress responses.View evidenceHide evidence
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Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis
Nature Aging · 2026
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Papers considered
The selected paper, plus nearby candidates.
Crossref, PubMed · 16 candidate papers
Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis
Nature Aging · 2026 · Crossref
Cellular Heterogeneity During Arterial Aging.
Aging Cell · 2026 · PubMed
Single-cell RNA sequencing reveals the heterogeneity of endothelial cells in human dupuytren’s disease
2023 · Crossref
Rejuvenation of the Aged Cerebrovascular System via Protein Corona-Guided Fusogenic Liposome Delivery.
bioRxiv : the Preprint Server for Biology · 2026 · PubMed
SULF1's Role in Endothelial Senescence and Atherosclerosis: Insights from Single-Cell and Bulk Transcriptomics.
Journal of Inflammation Research · 2025 · PubMed
Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas Projects; Systematic comparative analysis of single cell RNA-sequencing methods
2019 · Crossref
And 10 more candidates considered.