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Exercise is good for us—but why? (opens in a new tab)

medicalxpress.com · 2026-10-17

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Claim 1 of 7Not checkedSalk Institute researchers built a first-of-its-kind molecular atlas of how exercise reshapes the body, examining responses across organs, cell types, sexes and circadian phases in mice.View evidenceHide evidence

As stated22 tissues

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Claim 2 of 7Not checkedThe study used bulk RNA sequencing, metabolomics, proteomics, single-nucleus RNA sequencing and DNA methylation profiling to create a multi-omics atlas spanning 22 tissues.View evidenceHide evidence

As stated22 tissues

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Claim 3 of 7Not checkedThe researchers compared young male and female mice that either ran voluntarily on a wheel for eight weeks or remained sedentary.View evidenceHide evidence

As statedeight weeks

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Claim 4 of 7Not checkedExercise induced widespread, tissue-specific cellular remodeling, with most transcriptional changes occurring in skeletal muscle; no single gene changed in all 22 tissues.View evidenceHide evidence

As statednearly half the genes in at least one tissue

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Claim 5 of 7Not checkedThe atlas found sex- and circadian-phase differences, including broader transcriptional responses in females and stronger changes during the active phase in most tissues.View evidenceHide evidence

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Claim 6 of 7Not checkedThe team developed a 51-gene exercise signature that distinguishes exercise-trained from sedentary muscle in both mice and humans.View evidenceHide evidence

As stated51-gene

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Claim 7 of 7Not checkedThe article says the atlas is intended as a starting point for personalized exercise strategies, biomarker discovery, and future studies of how long exercise-induced changes last.View evidenceHide evidence

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Multi-omics atlas of chronic exercise

Cell · 2026

Source record (opens in a new tab)

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Papers considered

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Crossref, PubMed, Europe PMC · 16 candidate papers

And 10 more candidates considered.