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Esophageal cancer leaves a distinct metabolic signature in the gut (opens in a new tab)

news-medical.net · 2026-10-01

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Claim 1 of 5Not checkedResearchers uncovered distinctive gut microbial patterns and hundreds of altered fecal metabolites in people with esophageal cancer, with lipid metabolism standing out as a key signature.View evidenceHide evidence

As statedhundreds of altered fecal metabolites

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Claim 2 of 5Not checkedA recent Scientific Reports study investigated associations between gut microbiota, fecal metabolic alterations, and esophageal cancer using advanced metabolomic and 16S rRNA gene sequencing approaches.View evidenceHide evidence

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Claim 3 of 5Not checkedThe study enrolled 34 patients with esophageal cancer and 29 age-, gender-, and diet-matched healthy controls at HuLunBuir People’s Hospital in 2024, and analyzed fecal samples, serum tumor biomarkers, and esophageal tissue.View evidenceHide evidence

As stated34 patients and 29 controls

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Claim 4 of 5Not checkedMetabolomic profiling revealed 792 differential metabolites, and pathway analysis suggested dysregulation in lipid-related pathways including fatty acid transport, linoleic acid metabolism, glycerolipid metabolism, and PPARA-mediated lipid regulation.View evidenceHide evidence

As stated792 differential metabolites

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Claim 5 of 5Not checkedThe article says the findings should be interpreted cautiously because the study was retrospective and cross-sectional, the sample was small, many patients had already received anti-tumor treatment, and dietary differences may have influenced the results.View evidenceHide evidence

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Fecal metabolomic and microbiome profiling reveals lipid metabolic dysregulation in esophageal cancer

Scientific Reports · 2026

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Papers considered

The selected paper, plus nearby candidates.

Crossref, PubMed, Europe PMC · 16 candidate papers

Selected

Fecal metabolomic and microbiome profiling reveals lipid metabolic dysregulation in esophageal cancer

Scientific Reports · 2026 · Crossref

Source (opens in a new tab)
Candidate

Lipid Metabolism Profiling and Bladder Cancer

Journal of Postgenomics Drug & Biomarker Development · 2015 · Crossref

Source (opens in a new tab)
Candidate

Fiber Type Determines Feline Gut Microbiome Metabolism and Bioactive Lipid Profiles in Feces (P20-034-19)

Current Developments in Nutrition · 2019 · Crossref

Source (opens in a new tab)

And 10 more candidates considered.