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EARLY-PREG enables day-by-day tracking of thousands of proteins in the female reproductive tract (opens in a new tab)
medicalxpress.com · 2026-11-05
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EARLY-PREG enables day-by-day tracking of thousands of proteins in the female reproductive tract
medicalxpress.com · 2026-11-05
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Source study identified.
A source study was identified, but the study's evidence could not be prepared for claim assessment. No claim verdicts are available.
View article claimsThe source study
A dia-PASEF workflow improves proteome coverage and quantitative performance in repeated-measures analysis of cervicovaginal fluid from a preconception cohort (EARLY-PREG)
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Claim 1 of 8Not checkedA study by MELISA Institute, published in Scientific Reports, shows how researchers can track thousands of proteins in cervicovaginal fluid over seven consecutive days.View evidenceHide evidence
As statedthousands of proteins
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Claim 2 of 8Not checkedBy analyzing samples collected daily from the same women, the team could compare how well two workflows detected changes in protein abundance.View evidenceHide evidence
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Claim 3 of 8Not checkedIn a pioneering study of cervicovaginal fluid samples from the EARLY-PREG biobank, researchers at MELISA Institute validated a proteomics workflow that quantified about 50% more proteins than the comparison workflow.View evidenceHide evidence
As statedabout 50% more proteins
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Claim 4 of 8Not checkedThe dia-PASEF workflow quantified 4,229 proteins, compared with 2,817 for dda-FracOffline, and measurements were more consistent with dia-PASEF, which also detected more proteins whose abundance differed from the reference day.View evidenceHide evidence
As stated4,229 proteins vs 2,817 proteins
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Claim 5 of 8Not checkedUnder the study conditions, instrument acquisition took approximately one hour per sample with dia-PASEF, compared with 16 hours with dda-FracOffline.View evidenceHide evidence
As statedapproximately one hour per sample vs 16 hours
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Claim 6 of 8Not checkedThe method opens up new ways to study fertility, the earliest stages of pregnancy and biomarkers of clinical interest in the EARLY-PREG preconception cohort.View evidenceHide evidence
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Claim 7 of 8Not checkedThe study also tracked daily changes in CA-125 and HE4, and future studies in clinical populations could examine whether changes in these proteins are informative for diagnosis or monitoring disease progression and response to treatment.View evidenceHide evidence
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Claim 8 of 8Not checkedThe article says the study validated a measurement workflow, while the biological findings are exploratory and require confirmation in larger cohorts.View evidenceHide evidence
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A dia-PASEF workflow improves proteome coverage and quantitative performance in repeated-measures analysis of cervicovaginal fluid from a preconception cohort (EARLY-PREG)
Scientific Reports · 2026
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Papers considered
The selected paper, plus nearby candidates.
Crossref, PubMed, Europe PMC · 15 candidate papers
A dia-PASEF workflow improves proteome coverage and quantitative performance in repeated-measures analysis of cervicovaginal fluid from a preconception cohort (EARLY-PREG)
Scientific Reports · 2026 · Crossref
Translational resilience in intravaginal HIV prevention and multipurpose prevention technologies: formulation, exposure, and implementation barriers.
Journal of Controlled Release : Official Journal of the Controlled Release Society · 2026 · PubMed
A dia-PASEF workflow improves proteome coverage and quantitative performance in repeated-measures analysis of cervicovaginal fluid from a preconception cohort (EARLY-PREG)
2025 · Europe PMC, Crossref
Liquid Biopsy as a Screening Tool in Recurrent Implantation Failure During IVF: A Narrative Review.
Journal of Family & Reproductive Health · 2026 · PubMed
Early Acquisition Timing and CSF Venous Fistula Conspicuity on Lateral Decubitus CT Myelography.
AJNR. American Journal of Neuroradiology · 2026 · PubMed
Comparative Cross-Kingdom DDA- and DIA-PASEF Proteomic Profiling Reveals Novel Determinants of Fungal Virulence and a Putative Druggable Target
Crossref
And 9 more candidates considered.