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Decipher tissue-based molecular test helps personalize high-risk prostate cancer treatment (opens in a new tab)
news-medical.net · 2026-10-23
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Decipher tissue-based molecular test helps personalize high-risk prostate cancer treatment
news-medical.net · 2026-10-23
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Source study unconfirmed.
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Claim 1 of 5Not checkedUCL researchers will present findings suggesting that the Decipher tissue-based molecular test may help personalize treatment for men with high-risk prostate cancer.View evidenceHide evidence
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No source study was confirmed for this article. This claim remains unverified, rather than assessed as supported or unsupported.
Claim 2 of 5Not checkedThe team analyzed Decipher scores from two datasets: real-world data from 27,607 men, with 5,956 analyzed for outcomes, and 401 men with non-metastatic prostate cancer randomized within the STAMPEDE abiraterone trial.View evidenceHide evidence
As stated27,607 real-world cases; 5,956 analyzed for outcomes; 401 trial participants
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Claim 3 of 5Not checkedHigher Decipher scores consistently predicted worse outcomes; for every 0.1 increase in the score, the risk of distant metastasis increased with an adjusted hazard ratio of 1.49 and the risk of death from prostate cancer had a hazard ratio of 1.38.View evidenceHide evidence
As statedaHR 1.49 for distant metastasis; HR 1.38 for prostate cancer death per 0.1 score increase
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No source study was confirmed for this article. This claim remains unverified, rather than assessed as supported or unsupported.
Claim 4 of 5Not checkedThe Decipher score predicted which patients whose cancers had not yet spread to their lymph nodes would benefit from adding abiraterone in preventing spread to distant parts of the body.View evidenceHide evidence
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Claim 5 of 5Not checkedThe lead researcher said the findings suggest a genomic test could help personalize treatment by identifying men with low Decipher scores who might be spared more intensive treatment and men with high scores who could be prioritized for it, but further validation is needed before routine use.View evidenceHide evidence
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Search results
Candidate papers, not confirmed sources.
PubMed, Crossref, Europe PMC · 15 candidate papers
Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers.
Cell · 2025 · PubMed
Abiraterone May Offer Improved QOL Over Docetaxel in Locally Advanced/Metastatic Prostate Cancer
Default Digital Object Group · 2020 · Crossref
Optimal management of oligometastatic prostate cancer: current state and future directions.
2026 · Europe PMC
Clinical testing of transcriptome-wide expression profiles in high-risk localized and metastatic prostate cancer starting androgen deprivation therapy: an ancillary study of the STAMPEDE abiraterone Phase 3 trial.
Research Square · 2023 · PubMed
Abiraterone for “STAMPEDE-Like” cohort of high-risk prostate cancer in the PSMA-PET era: too much, too early?
Prostate Cancer and Prostatic Diseases · 2025 · Crossref