Common nutritional supplement may boost psoriasis treatment, small patient trial suggests (opens in a new tab)

medicalxpress.com · 2026-10-27

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Common nutritional supplement may boost psoriasis treatment, small patient trial suggests

medicalxpress.com · 2026-10-27

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Vanin-pantethine metabolic axis shapes dendritic cell function and affects inflammatory disorder progression
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Claim 1 of 4Not checkedThe study, published in the Journal of Experimental Medicine, shows that pantethine prevents the development of psoriasis in mice and also helps alleviate the symptoms of psoriasis patients in a small-scale human trial.View evidenceHide evidence

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Claim 2 of 4Not checkedResearchers in China have discovered that the vitamin B5 derivative pantethine limits the activity of immune cells that are key contributors to autoimmune diseases such as psoriasis.View evidenceHide evidence

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Claim 3 of 4Not checkedThe researchers found that vanin enzymes are elevated in dendritic cells from patients with psoriasis and several other autoimmune diseases, and that depleting these enzymes inhibited dendritic cell activation and limited their ability to activate T cells.View evidenceHide evidence

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Claim 4 of 4Not checkedIn a small-scale trial of 24 human psoriasis patients, everyone received topical calcipotriene/betamethasone ointment, and half also received pantethine tablets for 12 weeks; the added pantethine group showed improved symptoms, particularly among patients with elevated blood cholesterol.View evidenceHide evidence

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