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Cholesterol-sharing mechanism points to potential new target for pancreatic cancer treatment (opens in a new tab)
medicalxpress.com · 2026-10-30
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Cholesterol-sharing mechanism points to potential new target for pancreatic cancer treatment
medicalxpress.com · 2026-10-30
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ANO6-mediated trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer cell growth and immune suppression
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Claim 1 of 6Not checkedFox Chase Cancer Center researchers identified a potential therapeutic target for pancreatic cancer after showing that tumor growth can be slowed and immune suppression can be reduced in preclinical trials by blocking ANO6.View evidenceHide evidence
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Claim 2 of 6Not checkedThe study, published in Nature Cancer, found that ANO6 helps pancreatic cancer cells obtain nutrients from surrounding cells while suppressing the immune system's ability to fight tumors.View evidenceHide evidence
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Claim 3 of 6Not checkedANO6 enables cancer-associated fibroblasts to transfer cholesterol and other lipids to pancreatic cancer cells through trogocytosis.View evidenceHide evidence
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Claim 4 of 6Not checkedWhen researchers reduced or eliminated ANO6 in cancer-associated fibroblasts, the cells were less able to support pancreatic cancer cell survival, and in mouse models tumors supported by ANO6-positive CAFs grew substantially faster than those without functional ANO6.View evidenceHide evidence
As statedsubstantially faster
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Claim 5 of 6Not checkedBlocking ANO6 reduced cholesterol accumulation in tumor-infiltrating T cells, improved markers of T-cell activity, and laboratory experiments showed greater cancer-killing activity in T cells exposed to CAFs with reduced ANO6.View evidenceHide evidence
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Claim 6 of 6Not checkedIn mouse models, treatment with niclosamide or clofazimine, which inhibited ANO6-dependent activity in the study, significantly reduced tumor weight, and niclosamide also reduced cholesterol delivery to pancreatic cancer cells.View evidenceHide evidence
As statedsignificantly reduced
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ANO6-mediated trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer cell growth and immune suppression
Nature Cancer · 2026
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Papers considered
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Crossref, PubMed, Europe PMC · 16 candidate papers
ANO6-mediated trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer cell growth and immune suppression
Nature Cancer · 2026 · Crossref
Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6).
bioRxiv : the Preprint Server for Biology · 2023 · PubMed, Europe PMC
The prognostic significance of cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
2017 · Crossref
Metabolic and immune crosstalk between cancer-associated fibroblasts and pancreatic cancer cells.
2025 · Europe PMC
Nectin-1 expression in cancer-associated fibroblasts is associated with poor prognosis of pancreatic ductal adenocarcinoma
2016 · Crossref
Inter- and intra-tumoral heterogeneity and dynamics of cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
Crossref
And 10 more candidates considered.