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Brain scans show shared changes during depression treatment and distinct antidepressant effects in some patients (opens in a new tab)

medicalxpress.com · 2026-10-03

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Study found.

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1

The story

Brain scans show shared changes during depression treatment and distinct antidepressant effects in some patients

medicalxpress.com · 2026-10-03

The story’s checkable claims.

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2

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Evidence layer

Claim by claim

The source study was found, but the study's evidence could not be profiled, so these claims couldn't be checked.

Claim 1 of 5Not checkedResearchers analyzed brain scans from 386 people with major depressive disorder to study how functional connectivity changed during the first one or two weeks after starting placebo, sertraline, or escitalopram.View evidenceHide evidence

As stated386 participants; 1 or 2 weeks; 3 treatment groups

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The source study was found, but this claim couldn't be checked against it.

Claim 2 of 5Not checkedThe paper describes brain connectivity changes shared across treatment groups, regardless of whether symptoms improved.View evidenceHide evidence

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The source study was found, but this claim couldn't be checked against it.

Claim 3 of 5Not checkedIn the placebo group, symptom improvement was associated with changes involving the striatum and attention networks.View evidenceHide evidence

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The source study was found, but this claim couldn't be checked against it.

Claim 4 of 5Not checkedDrug-specific functional connectivity effects involving the amygdala, midcingulate, orbitofrontal cortex and cerebellum were seen only in a subset of patients treated with antidepressants.View evidenceHide evidence

As statedsubset of patients

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The source study was found, but this claim couldn't be checked against it.

Claim 5 of 5Not checkedThe article says the findings could eventually help clinicians plan treatment using brain scans collected shortly after a patient starts a new medication, but more research is needed before the patterns can guide clinical practice.View evidenceHide evidence

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The source study was found, but this claim couldn't be checked against it.

Finally, the search trail

Method layer

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Open the paper in Tessa

Early brain functional connectivity changes induced by antidepressants and placebo

Nature Mental Health · 2026

Source record (opens in a new tab)

Why this one

Near certain

NewsLink found the paper. Tessa is where you inspect it deeply.

Papers considered

The selected paper, plus nearby candidates.

Crossref, PubMed, Europe PMC · 40 candidate papers

Selected

Early brain functional connectivity changes induced by antidepressants and placebo

Nature Mental Health · 2026 · Crossref

Source (opens in a new tab)
Candidate

Author Correction: Macroeconomic income inequality, brain structure and function, and mental health

Nature Mental Health · 2026 · Crossref

Source (opens in a new tab)

And 34 more candidates considered.