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Blocking cellular communication reduces the spread of deadly glioblastoma (opens in a new tab)
news-medical.net · 2026-10-27
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Blocking cellular communication reduces the spread of deadly glioblastoma
news-medical.net · 2026-10-27
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Macrophage lipid signaling drives glioblastoma invasion and represents a therapeutic vulnerability
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Claim 1 of 6Not checkedIn a new study published in Cancer Cell, researchers at VIB-KU Leuven reduced the spread of glioblastoma by interrupting specific interactions between the brain's immune cells and tumor cells.View evidenceHide evidence
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Claim 2 of 6Not checkedThe researchers found that tumor cells use lipids released by microglia to become more mobile and invade healthy areas of the brain.View evidenceHide evidence
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Claim 3 of 6Not checkedMicroglia release a specific type of lipid called lysophosphatidic acids (LPAs) that binds to tumor cells and activates pathways that help them spread to further areas of the brain.View evidenceHide evidence
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Claim 4 of 6Not checkedBlocking this interaction made tumors less invasive, although the size of the tumor did not change.View evidenceHide evidence
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Claim 5 of 6Not checkedThe authors suggest the approach could be used before surgery to make glioblastomas more contained and easier to remove, and that it could potentially be combined with therapies that reduce tumor size.View evidenceHide evidence
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Claim 6 of 6Not checkedThe researchers also report that similar patterns were seen in human samples and patient-derived tumor cell lines, suggesting the findings could translate to patients.View evidenceHide evidence
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Macrophage lipid signaling drives glioblastoma invasion and represents a therapeutic vulnerability
Cancer Cell · 2026
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Papers considered
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Crossref, PubMed · 33 candidate papers
Macrophage lipid signaling drives glioblastoma invasion and represents a therapeutic vulnerability
Cancer Cell · 2026 · Crossref
Microglial lipid signaling drives glioblastoma invasion and represents a therapeutic vulnerability
2026 · Crossref
Reply on RC2
2026 · Crossref
Reply on RC3
2026 · Crossref
Reply on RC1
2026 · Crossref
Author response for "Wax-printing-free fabrication of paper-supported 3D cancer cell culture"
2026 · Crossref
And 27 more candidates considered.