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Biological rejuvenation of older hearts in young recipients (opens in a new tab)

news-medical.net · 2026-10-05

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and 14 more considered

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Claim 1 of 5Not checkedOlder hearts transplanted into younger recipients showed signs of biological rejuvenation in a new bioRxiv preprint.View evidenceHide evidence

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Claim 2 of 5Not checkedThe study reports that transplanted hearts can shift toward the biological age of their recipients, with younger hearts in older recipients appearing biologically older and older hearts in younger recipients showing molecular signatures consistent with rejuvenation.View evidenceHide evidence

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Claim 3 of 5Not checkedIn mouse heterotopic heart transplantation experiments, DNA methylation clocks and transcriptomic analyses suggested age-matched molecular changes in the transplanted hearts, while the recipient’s native heart, liver, and blood mostly remained unchanged.View evidenceHide evidence

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Claim 4 of 5Not checkedThe human analysis of biopsy samples from 11 transplant recipients showed a similar pattern, with estimated biological age of transplanted hearts associated with recipient age.View evidenceHide evidence

As stated11 transplant recipients

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Claim 5 of 5Not checkedThe article says recipient age was associated with some one-year post-transplant functional outcomes, most consistently exercise capacity, but notes that longer-term studies are needed and that the preprint is not peer reviewed.View evidenceHide evidence

As statedone year after heart transplantation

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PubMed, Crossref, Europe PMC · 15 candidate papers

Candidate

Comparable Rates of Severe Primary Graft DysfunctionAfter Heart Transplantation in Recipients With Prior LVAD or Other Cardiac Surgery: The Burden of Surgical Reentry.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation · 2026 · PubMed

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And 10 more candidates considered.