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AI study of 101,000 patients links brown fat to heart and mental health (opens in a new tab)

news-medical.net · 2026-10-15

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Claim 1 of 7Not checkedResearchers published a Nature study that used artificial intelligence and large clinical datasets to systematically map clinical phenotypes associated with human brown adipose tissue.View evidenceHide evidence

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Claim 2 of 7Not checkedThe researchers analyzed 18F-FDG-PET-CT scans from 101,243 adult patients to examine associations between brown fat and health outcomes.View evidenceHide evidence

As stated101,243 adult patients

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Claim 3 of 7Not checkedDetectable BAT was associated with a lower prevalence of cardiometabolic and psychiatric conditions, and higher measured activity in individual BAT depots was linked to more favorable cardiometabolic outcomes.View evidenceHide evidence

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Claim 4 of 7Not checkedThe study’s pharmacological profiling identified the antihypertensive drug losartan as a candidate for further investigation.View evidenceHide evidence

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Claim 5 of 7Not checkedExperiments in cultured fat cells and mice found increased thermogenic activity and energy expenditure with losartan, but the article says the drug has not been tested for effects on human BAT in clinical trials.View evidenceHide evidence

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Claim 6 of 7Not checkedThe article says the study could not establish that brown fat prevents disease and notes limitations including its retrospective design and a cancer-center-restricted population.View evidenceHide evidence

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Claim 7 of 7Not checkedThe article reports that the laboratory and mouse findings suggest losartan warrants further investigation as a BAT-activating treatment, while its effectiveness in humans remains unknown.View evidenceHide evidence

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Artificial intelligence-enabled clinical phenotyping of human brown fat

Nature · 2026

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Papers considered

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Crossref, PubMed, Europe PMC · 16 candidate papers

Candidate

Prevalence and factors associated with brown adipose tissue detected by 18F-FDG PET/CT in Hong Kong Chinese

Crossref

Source (opens in a new tab)
Candidate

Figure 4. Detection of brown adipose tissue according to 18F-FDG PET-CT in patients with different body weights in the van Marken Lichtenbelt WD study (2009) [47].

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And 10 more candidates considered.