A Single Enzyme Could Hold the Key to Treating a Devastating Brain Disorder (opens in a new tab)

scitechdaily.com · 2026-10-25

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A Single Enzyme Could Hold the Key to Treating a Devastating Brain Disorder

scitechdaily.com · 2026-10-25

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Source study unconfirmed.

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10.1038/s41586-026-11165-4
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Claim 1 of 4Not checkedBlocking an enzyme’s production restored brain growth and healthy behaviors in mice engineered to develop Angelman syndrome, pointing to a possible treatment target.View evidenceHide evidence

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Claim 2 of 4Not checkedResearchers traced the effects of missing UBE3A to a buildup of asparagine synthetase that triggered a brain stress response interfering with brain growth.View evidenceHide evidence

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Claim 3 of 4Not checkedThe study identified 23 candidate proteins that accumulated when UBE3A was deactivated in laboratory cells, and asparagine synthetase stood out as the main suspect.View evidenceHide evidence

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Claim 4 of 4Not checkedYi said medications could potentially target the stress response triggered by asparagine synthetase, but much remains to be learned before treatment work can begin.View evidenceHide evidence

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