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A missing piece in the cell death and inflammation signaling pathway puzzle has been revealed (opens in a new tab)
medicalxpress.com · 2026-09-28
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A missing piece in the cell death and inflammation signaling pathway puzzle has been revealed
medicalxpress.com · 2026-09-28
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Open claim evidenceThe source study
HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death
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Claim 1 of 6Not checkedAn international research team discovered a previously unknown mechanism that plays a key role in programmed cell death signaling pathways.View evidenceHide evidence
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Claim 2 of 6Not checkedThe team identified HERC4 as an essential component of both TNF-induced necroptosis and apoptosis pathways.View evidenceHide evidence
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Claim 3 of 6Not checkedThe study, titled 'HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death,' was published in Nature Structural and Molecular Biology.View evidenceHide evidence
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Claim 4 of 6Not checkedThe article says HERC4 acts as a critical switch that helps TNF signaling move from a survival signal to a death signal by binding and ubiquitinating RIPK1.View evidenceHide evidence
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Claim 5 of 6Not checkedMouse models showed that mice lacking HERC4 were protected against TNF-induced systemic inflammatory responses and TNF-mediated acute liver damage.View evidenceHide evidence
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Claim 6 of 6Not checkedThe researchers speculate that HERC4 inhibitors could become oral drugs with broader activity than TNF inhibitors.View evidenceHide evidence
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HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death
Nature Structural & Molecular Biology · 2026
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Papers considered
The selected paper, plus nearby candidates.
Crossref, PubMed, Europe PMC · 15 candidate papers
HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death
Nature Structural & Molecular Biology · 2026 · Crossref
HERC4 synergizes with USP16 to promote lung adenocarcinoma growth by augmenting protein translation via stabilizing RPS15.
Oncogene · 2026 · PubMed
Regulatory role of E3 ubiquitin ligases in multiple myeloma: from molecular mechanisms to therapeutic strategies.
2025 · Europe PMC
HERC4 suppresses colorectal cancer progression by promoting STAT3 ubiquitination.
iScience · 2026 · PubMed
Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death
Cell Death & Differentiation · 2021 · Crossref
E3 ubiquitin ligases: structural diversity, dysregulation in disease, and their emerging role in targeted therapeutic strategies.
2026 · Europe PMC
And 9 more candidates considered.