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A Hidden Compound in 'Healthy' Plant-Based Foods May Be Fueling Gut Inflammation : ScienceAlert (opens in a new tab)

sciencealert.com · 2026-10-02

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Claim 1 of 7Not checkedA new study suggests that some plant-based foods, because they contain oxalate, could be linked to inflammatory bowel disease and gut inflammation.View evidenceHide evidence

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Claim 2 of 7Not checkedThe research, led by University of North Carolina researchers, focuses on oxalate, a natural compound found in all plant-based foods, and suggests that problems processing it may contribute to gut issues in some people.View evidenceHide evidence

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Claim 3 of 7Not checkedIn one part of the study, diet and stool measurements in 46 participants suggested that Crohn's disease patients had more oxalate in their stool than healthy controls despite similar plant-based food intake.View evidenceHide evidence

As stated46 participants

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Claim 4 of 7Not checkedIn several hundred tissue samples from people with Crohn's disease, ulcerative colitis, and healthy controls, genes for oxalate transporter proteins SLC26A2 and SLC26A3 were reported to be less active in IBD samples.View evidenceHide evidence

As statedseveral hundred tissue samples

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Claim 5 of 7Not checkedMouse experiments in an inflamed-gut model found that extra dietary oxalate worsened weight loss, intestinal inflammation, and survival.View evidenceHide evidence

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Claim 6 of 7Not checkedLab tests on mouse immune cells suggested oxalate increased inflammatory responses, which the article says points to an immune reaction rather than direct tissue damage.View evidenceHide evidence

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Claim 7 of 7Not checkedThe story says the researchers see dietary oxalate as a potentially modifiable factor in intestinal inflammation and suggest future work could target oxalate transporters or oxalate-clearing bacteria.View evidenceHide evidence

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Papers considered

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Crossref, PubMed, Europe PMC · 16 candidate papers

And 10 more candidates considered.